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Moxifloxacin/Metronidazole or Piperacillin/Tazobactam
Moxifloxacin/Metronidazole or Piperacillin/Tazobactam is a Broad-spectrum antibiotic combination Small molecule drug developed by Hannover Medical School. It is currently in Phase 3 development for Intra-abdominal infections with mixed aerobic and anaerobic flora, Complicated appendicitis or peritonitis.
This is a combination antibiotic regimen that uses fluoroquinolone and nitroimidazole agents (or beta-lactam with beta-lactamase inhibitor) to provide broad-spectrum coverage against aerobic and anaerobic bacteria.
This is a combination antibiotic regimen that uses fluoroquinolone and nitroimidazole agents (or beta-lactam with beta-lactamase inhibitor) to provide broad-spectrum coverage against aerobic and anaerobic bacteria. Used for Intra-abdominal infections with mixed aerobic and anaerobic flora, Complicated appendicitis or peritonitis.
At a glance
| Generic name | Moxifloxacin/Metronidazole or Piperacillin/Tazobactam |
|---|---|
| Sponsor | Hannover Medical School |
| Drug class | Broad-spectrum antibiotic combination |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Moxifloxacin is a fluoroquinolone that inhibits bacterial DNA gyrase and topoisomerase IV, while metronidazole is a nitroimidazole that generates reactive intermediates to damage anaerobic bacterial DNA. Alternatively, piperacillin/tazobactam combines a broad-spectrum penicillin with a beta-lactamase inhibitor to overcome resistance mechanisms. Together, these combinations provide synergistic coverage of gram-positive, gram-negative, and anaerobic pathogens.
Approved indications
- Intra-abdominal infections with mixed aerobic and anaerobic flora
- Complicated appendicitis or peritonitis
Common side effects
- Diarrhea
- Nausea
- Abdominal pain
- Metallic taste (metronidazole)
- Tendinopathy (fluoroquinolone)
- Photosensitivity (fluoroquinolone)
Key clinical trials
- Comparing Oral Versus Parenteral Antimicrobial Therapy (PHASE4)
- Patients Response to Early Switch To Oral:Osteomyelitis Study (EARLY_PHASE1)
- Moxifloxacin Plus Metronidazole Versus Piperacillin/Tazobactam for the Treatment of Patients With Intra-abdominal Abscesses (PHASE3)
- Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for Osteomyelitis (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Moxifloxacin/Metronidazole or Piperacillin/Tazobactam CI brief — competitive landscape report
- Moxifloxacin/Metronidazole or Piperacillin/Tazobactam updates RSS · CI watch RSS
- Hannover Medical School portfolio CI
Frequently asked questions about Moxifloxacin/Metronidazole or Piperacillin/Tazobactam
What is Moxifloxacin/Metronidazole or Piperacillin/Tazobactam?
How does Moxifloxacin/Metronidazole or Piperacillin/Tazobactam work?
What is Moxifloxacin/Metronidazole or Piperacillin/Tazobactam used for?
Who makes Moxifloxacin/Metronidazole or Piperacillin/Tazobactam?
What drug class is Moxifloxacin/Metronidazole or Piperacillin/Tazobactam in?
What development phase is Moxifloxacin/Metronidazole or Piperacillin/Tazobactam in?
What are the side effects of Moxifloxacin/Metronidazole or Piperacillin/Tazobactam?
Related
- Drug class: All Broad-spectrum antibiotic combination drugs
- Manufacturer: Hannover Medical School — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Intra-abdominal infections with mixed aerobic and anaerobic flora
- Indication: Drugs for Complicated appendicitis or peritonitis
- Compare: Moxifloxacin/Metronidazole or Piperacillin/Tazobactam vs similar drugs
- Pricing: Moxifloxacin/Metronidazole or Piperacillin/Tazobactam cost, discount & access