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Mouthwash CHX
Chlorhexidine mouthwash works by disrupting bacterial cell membranes, ultimately leading to cell death.
Chlorhexidine mouthwash works by disrupting bacterial cell membranes, ultimately leading to cell death. Used for Prevention of oral infections.
At a glance
| Generic name | Mouthwash CHX |
|---|---|
| Also known as | Pre-procedural mouthwash |
| Sponsor | University of Guarulhos |
| Drug class | Antimicrobial |
| Modality | Small molecule |
| Therapeutic area | Dentistry |
| Phase | Phase 3 |
Mechanism of action
Chlorhexidine mouthwash exerts its antimicrobial effects by binding to negatively charged bacterial cell membranes, causing cell lysis and death. This results in a reduction of bacterial load in the oral cavity, which can help prevent infections and promote oral health.
Approved indications
- Prevention of oral infections
Common side effects
- Gingivitis
- Oral mucosal irritation
Key clinical trials
- PMPR and Chlorhexidine on Periodontal Disease and Vascular Function (NA)
- To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse. (NA)
- Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer (PHASE2)
- Dental Biofilm Control During Orthodontic Treatment (PHASE3)
- Efficacy of Two Daily - Use CHX Based Mouth Rinses on Microbial Biofilm Accumulation, Gingivitis Development, and Staining (PHASE3)
- Effectiveness of Herbal vs Chlorhexidine Mouthwashes in Improving Oral Health in Schoolchildren (NA)
- Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices (NA)
- Effect of a Mouthwash Containing Chlorhexidine and Chlorine Dioxide on Halitosis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Mouthwash CHX CI brief — competitive landscape report
- Mouthwash CHX updates RSS · CI watch RSS
- University of Guarulhos portfolio CI