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morphine ,ketorolac
This is a combination of morphine (an opioid agonist) and ketorolac (an NSAID) that work together to provide analgesia through different pathways.
This is a combination of morphine (an opioid agonist) and ketorolac (an NSAID) that work together to provide analgesia through different pathways. Used for Moderate to severe acute pain, Postoperative pain.
At a glance
| Generic name | morphine ,ketorolac |
|---|---|
| Sponsor | Jose Antonio Bernia Gil |
| Drug class | Opioid analgesic + NSAID combination |
| Target | Opioid receptors (μ, δ, κ); COX-1 and COX-2 enzymes |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Morphine binds to opioid receptors in the central nervous system to reduce pain perception and emotional response to pain. Ketorolac inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and peripheral inflammation. Together, they provide multimodal analgesia for moderate to severe pain.
Approved indications
- Moderate to severe acute pain
- Postoperative pain
Common side effects
- Nausea
- Dizziness
- Constipation
- Gastrointestinal upset
- Drowsiness
- Headache
Key clinical trials
- Examining Analgesic Synergy and Efficacy in Trauma Care (PHASE4)
- Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy (PHASE2, PHASE3)
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Anesthetics and Analgesics in Children
- Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy (PHASE3)
- Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid (PHASE2)
- Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- morphine ,ketorolac CI brief — competitive landscape report
- morphine ,ketorolac updates RSS · CI watch RSS
- Jose Antonio Bernia Gil portfolio CI