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Morphine 6-glucuronide
Morphine 6-glucuronide is an active metabolite of morphine that binds to opioid receptors in the central nervous system to produce analgesia and other opioid effects.
Morphine 6-glucuronide is an active metabolite of morphine that binds to opioid receptors in the central nervous system to produce analgesia and other opioid effects. Used for Acute and chronic pain management, Postoperative pain.
At a glance
| Generic name | Morphine 6-glucuronide |
|---|---|
| Sponsor | Paion UK Ltd. |
| Drug class | Opioid receptor agonist |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Morphine 6-glucuronide (M6G) is formed through hepatic glucuronidation of morphine and acts as a mu-opioid receptor agonist. It crosses the blood-brain barrier and produces potent analgesic effects, potentially with a more favorable side effect profile than morphine itself. M6G accumulates in renal impairment, making it a consideration in pain management across different patient populations.
Approved indications
- Acute and chronic pain management
- Postoperative pain
Common side effects
- Respiratory depression
- Nausea and vomiting
- Constipation
- Dizziness
- Sedation
Key clinical trials
- An Efficacy and Safety Study to Compare Morphine 6-glucuronide (M6G) and Morphine in Patients Suffering With Post-Operative Pain for at Least 24 Hours (PHASE3)
- Development of a Morphine Pharmacokinetic and Pharmacodynamic Model for the Neonatal Population (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Morphine 6-glucuronide CI brief — competitive landscape report
- Morphine 6-glucuronide updates RSS · CI watch RSS
- Paion UK Ltd. portfolio CI