Last reviewed · How we verify
Mona Lisa® NT Cu380 Mini
A copper-containing intrauterine device that prevents pregnancy by releasing copper ions that create a hostile environment for sperm and embryo implantation.
A copper-containing intrauterine device that prevents pregnancy by releasing copper ions that create a hostile environment for sperm and embryo implantation. Used for Contraception in women of reproductive age.
At a glance
| Generic name | Mona Lisa® NT Cu380 Mini |
|---|---|
| Also known as | NT380-Mini, NTCu380-Mini |
| Sponsor | FHI 360 |
| Drug class | Intrauterine device (IUD), copper-based contraceptive |
| Modality | Small molecule |
| Therapeutic area | Contraception / Reproductive Health |
| Phase | Phase 3 |
Mechanism of action
The Mona Lisa NT Cu380 Mini is a non-hormonal intrauterine contraceptive device that works through copper-mediated mechanisms. The copper ions released from the device surface inhibit sperm motility and viability, and alter the endometrial environment to prevent fertilization and implantation. This mechanical and chemical approach provides long-acting reversible contraception without systemic hormonal effects.
Approved indications
- Contraception in women of reproductive age
Common side effects
- Increased menstrual bleeding
- Menstrual cramping
- Device expulsion
- Perforation
- Pelvic infection
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Mona Lisa® NT Cu380 Mini CI brief — competitive landscape report
- Mona Lisa® NT Cu380 Mini updates RSS · CI watch RSS
- FHI 360 portfolio CI