Last reviewed · How we verify
mometasone furoate plus azelastine HCl
Mometasone furoate is a corticosteroid that reduces inflammation, while azelastine HCl is an antihistamine that blocks histamine receptors.
Mometasone furoate is a corticosteroid that reduces inflammation, while azelastine HCl is an antihistamine that blocks histamine receptors. Used for Allergic conjunctivitis.
At a glance
| Generic name | mometasone furoate plus azelastine HCl |
|---|---|
| Also known as | Nasaflex Nasal Spray |
| Sponsor | Hanlim Pharm. Co., Ltd. |
| Drug class | Corticosteroid and antihistamine combination |
| Target | Histamine receptors (H1) |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | Phase 3 |
Mechanism of action
Mometasone furoate works by inhibiting the release of pro-inflammatory cytokines and mediators, thereby reducing inflammation. Azelastine HCl, on the other hand, blocks histamine receptors, which are involved in allergic responses and inflammation.
Approved indications
- Allergic conjunctivitis
Common side effects
- Eye irritation
Key clinical trials
- Study to Compare the Pharmacokinetics of Fixed-Dose Combination of Mometasone + Azelastine Nasal Spray to Mometasone and Azelastine Nasal Sprays in Adolescents and Young Adults With Seasonal Allergic Rhinitis (PHASE1)
- Efficacy and Safety of Fixed Dose Combination (FDC) of Olopatadine Hydrochloride and Mometasone Furoate Nasal Spray (Molo; Also Referred as GSP 301) in the Treatment of Seasonal Allergic Rhinitis (SAR) (PHASE2)
- A Study to Evaluate the Safety and Tolerability of a Nasal Spray to Treat Perennial Allergic Rhinitis (PHASE3)
- Efficacy and Safety of Mometasone Furoate Plus Azelastine HCl Combination Versus Mometasone Furoate Alone or Azelastine Alone in Patients With Perennial Allergic Rhinitis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: