Last reviewed 2026-04-22 · How we verify

moisturizing cream

A topical moisturizing cream hydrates and protects the skin barrier by occluding moisture and providing emollient ingredients.

A topical moisturizing cream hydrates and protects the skin barrier by occluding moisture and providing emollient ingredients. Used for Dry skin, Skin barrier maintenance.

At a glance

Mechanism of action

Moisturizing creams work by forming a protective layer on the skin surface that reduces transepidermal water loss and helps restore skin hydration. The emollient and humectant ingredients penetrate or coat the stratum corneum to improve skin softness, elasticity, and overall barrier function. This mechanism is particularly useful for managing dry skin conditions and maintaining skin health.

Approved indications

• Dry skin
• Skin barrier maintenance

Common side effects

• Local irritation or sensitization
• Contact dermatitis

Key clinical trials

• Skin Barrier Function and Inflammation in Aging: The BIA Study (PHASE4)
• Effect of Pulsed Electromagnetic Field on Pruritus in Burn Scars (NA)
• Care Bundle for Prevention of Skin Complications and Edema in Restrained Patients (NA)
• Exploratory Clinical Investigation on Neurosensory Responses Via EEG Headband in Adults With Mild to Moderate Atopic Dermatitis After Application of Marketed Product Compared With Placebo (Water Application). (NA)
• Moisturization and Skin Hydration Study (NA)
• Efficacy of Four Topical Products to Improve Skin Longevity (NA)
• CeraVe Effect on Restoring Skin Hydration as Maintenance Regimen in Subjects With Mild to Moderate Atopic Dermatitis (NA)
• Photobiomodulation in the Treatment of Hand-foot Syndrome (NA)

Primary sources

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