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Mineral Tri-Oxide Aggregate
Mineral Tri-Oxide Aggregate (MTA) is a biocompatible cement that sets through a hydration reaction, creating a hard matrix that seals and promotes healing in dental and endodontic applications.
Mineral Tri-Oxide Aggregate (MTA) is a biocompatible cement that sets through a hydration reaction, creating a hard matrix that seals and promotes healing in dental and endodontic applications. Used for Pulp capping and vital pulp therapy, Apical barrier formation in immature teeth, Root perforation repair.
At a glance
| Generic name | Mineral Tri-Oxide Aggregate |
|---|---|
| Also known as | MTA |
| Sponsor | DR SURINDER SACHDEVA |
| Modality | Small molecule |
| Therapeutic area | Dentistry/Endodontics |
| Phase | FDA-approved |
Mechanism of action
MTA consists of Portland cement and bismuth oxide, which hydrate to form calcium silicate hydrate gel and calcium hydroxide. This creates a biocompatible, antimicrobial barrier that promotes periapical healing, remineralization, and hard tissue formation. It is used primarily in endodontics for root canal treatment, perforation repair, and apical barrier formation.
Approved indications
- Endodontic treatment and root canal sealing
- Perforation repair in teeth
- Apical barrier formation
- Pulp capping and pulpotomy
- Periapical lesion treatment
Common side effects
- Discoloration of tooth structure
- Difficulty in removal if over-extended
- Allergic reaction (rare)
Key clinical trials
- Epigallocatechin Gallate (EGCG) as a Flushing Agent During Full Pulpotomy in Mature Permanent Molars With Irreversible Pulpitis (NA)
- Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical Lesions (NA)
- Short Term Comparative Assessment of MTA and Biodentine in Complete Pulpotomy for Symptomatic Irreversible Pulpitis (NA)
- Single Versus Multiple Visits Regenerative Endodontics in Mature Teeth (NA)
- Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth (PHASE4)
- Comparative Evaluation of Calcium Silicate-doped Treated Dentin Matrix and Mineral Trioxide Aggregate as Miniature Pulpotomy Biomaterials in Deep Carious Lesions (NA)
- Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth (PHASE3)
- Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Mineral Tri-Oxide Aggregate CI brief — competitive landscape report
- Mineral Tri-Oxide Aggregate updates RSS · CI watch RSS
- DR SURINDER SACHDEVA portfolio CI