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Midazolam+Fentanyl Combination
Midazolam and fentanyl work synergistically as a benzodiazepine and opioid combination to produce sedation, analgesia, and anxiolysis through GABA and opioid receptor agonism.
Midazolam and fentanyl work synergistically as a benzodiazepine and opioid combination to produce sedation, analgesia, and anxiolysis through GABA and opioid receptor agonism. Used for Procedural sedation and analgesia, Critical care sedation, Preoperative anxiolysis and analgesia.
At a glance
| Generic name | Midazolam+Fentanyl Combination |
|---|---|
| Also known as | Midazolam, Fentanyl |
| Sponsor | Universidad de Cartagena |
| Drug class | Benzodiazepine + Opioid combination |
| Target | GABA-A receptor (midazolam); Mu-opioid receptor (fentanyl) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia, Sedation, Pain Management |
| Phase | FDA-approved |
Mechanism of action
Midazolam is a short-acting benzodiazepine that enhances GABAergic inhibitory neurotransmission in the central nervous system, producing sedation and anxiolysis. Fentanyl is a potent synthetic opioid agonist that binds to mu-opioid receptors to produce analgesia and respiratory depression. The combination is used to achieve rapid onset sedation with concurrent pain relief, commonly employed in procedural and critical care settings.
Approved indications
- Procedural sedation and analgesia
- Conscious sedation for diagnostic and therapeutic procedures
- Sedation in critical care and intensive care settings
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Oversedation
- Nausea and vomiting
- Dizziness
Key clinical trials
- Prospective IR-led Sedation Feasibility (PHASE1, PHASE2)
- General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound (NA)
- Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology (EARLY_PHASE1)
- Investigation of the Effects of Two Different Anaesthesia Methods Applied to Patients Scheduled for Arthroscopic Knee Surgery on the Heart (NA)
- Attenuate the Stress Response in Laparoscopic Cholecystectomy (PHASE4)
- Comparison of Prolotherapy and Rehabilitation Treatments in Low Back Pain (CPRTLBP) (NA)
- Clinical Outcomes of Sedation in Cataract Surgery Performed Under Topical Anesthesia (NA)
- Analgesic Effect of Supraclavicular Block and Interscalene Analgesia Versus an Intercostobrachial Nerve Block Versus PCA in Forearm Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Midazolam+Fentanyl Combination CI brief — competitive landscape report
- Midazolam+Fentanyl Combination updates RSS · CI watch RSS
- Universidad de Cartagena portfolio CI