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Midazolam and fentanyl
Midazolam and fentanyl together provide sedation and analgesia by enhancing GABAergic inhibition in the central nervous system and activating opioid receptors, respectively.
Midazolam is a benzodiazepine that enhances GABA inhibitory signaling in the central nervous system, while fentanyl is an opioid agonist that binds mu opioid receptors to produce analgesia and sedation. Used for Procedural sedation and analgesia, Conscious sedation for diagnostic and therapeutic procedures.
At a glance
| Generic name | Midazolam and fentanyl |
|---|---|
| Also known as | Versed (Midazolam), Fentanyl Citrate Injection, USP (Fentanyl), Versed, Sublimaze |
| Sponsor | Corewell Health East |
| Drug class | Benzodiazepine and opioid combination |
| Target | GABA-A receptor (midazolam); mu opioid receptor (fentanyl) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Sedation |
| Phase | FDA-approved |
Mechanism of action
Midazolam is a benzodiazepine that potentiates GABA-A receptor signaling to produce sedation, anxiolysis, and amnesia. Fentanyl is a synthetic opioid agonist at mu-opioid receptors that produces analgesia and respiratory depression. This combination is used for procedural sedation and anesthesia, where the synergistic effects provide both pain relief and sedation.
Approved indications
- Procedural sedation and analgesia
- Induction and maintenance of general anesthesia
- Conscious sedation for diagnostic and therapeutic procedures
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Oversedation
- Nausea and vomiting
- Dizziness
Key clinical trials
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids (NA)
- Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical Thoracoscopy (PHASE3)
- The Impact of a Shared Decision-Making Intervention on Intraoperative Patient Experience During Elective Cesarean Delivery Under Spinal Anesthesia (NA)
- Virtual Reality to Improve Patient Experience During Endoscopic Mucosal and Submucosal Resection (NA)
- Prospective IR-led Sedation Feasibility (PHASE1, PHASE2)
- General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound (NA)
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Midazolam and fentanyl CI brief — competitive landscape report
- Midazolam and fentanyl updates RSS · CI watch RSS
- Corewell Health East portfolio CI