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Microfragmented Adipose Tissue Transplant
Microfragmented adipose tissue transplant delivers regenerative cells and bioactive factors from processed fat tissue to promote tissue repair and reduce inflammation.
Microfragmented adipose tissue transplant delivers regenerative cells and bioactive factors from processed fat tissue to promote tissue repair and reduce inflammation. Used for Cartilage defects and osteoarthritis, Soft tissue injuries.
At a glance
| Generic name | Microfragmented Adipose Tissue Transplant |
|---|---|
| Also known as | aMAT |
| Sponsor | American University of Beirut Medical Center |
| Drug class | Cell therapy / Regenerative medicine |
| Modality | Biologic |
| Therapeutic area | Regenerative Medicine / Orthopedics |
| Phase | Phase 3 |
Mechanism of action
The procedure involves harvesting autologous adipose tissue, microfragmenting it to increase surface area and cell viability, and transplanting it to damaged or degenerative tissue sites. The transplanted tissue contains adipose-derived stem cells, stromal vascular fraction cells, and secreted factors that promote angiogenesis, reduce inflammation, and stimulate endogenous repair mechanisms.
Approved indications
- Cartilage defects and osteoarthritis
- Soft tissue injuries
Common side effects
- Injection site pain or swelling
- Infection at harvest or injection site
- Temporary inflammation
Key clinical trials
- Prospective Clinical Study to Evaluate the Safety and Efficacy of Intraarticular Administration of Micro-grafts of Adipose Tissue (Adipo-micro-grafts) in the Treatment of Osteoarthritis of the Trapezium-metacarpal Joint (ADIPO_MICRO_GRAFTS_1) (NA)
- Assessment of Dimensional Changes Following Grafting With Microfragmented Adipose Tissue Loaded on Allograft on Ridge Preservation (NA)
- Assessment of Microfragmented Adipose Tissue Loaded on Bovine Graft Versus Bovine Graft Only on Ridge Preservation. (NA)
- Treatment of Osteoarthritis With Autologous, Microfragmented Adipose Tissue. (NA)
- Effects of α MAT Versus Steroid Injection in Knee Osteoarthritis (STα MAT-knee Study) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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