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Mg Oxide
Magnesium oxide acts as an osmotic laxative and magnesium supplement by drawing water into the intestinal lumen to promote bowel movements and increase serum magnesium levels.
Magnesium oxide acts as an osmotic laxative and magnesium supplement by drawing water into the intestinal lumen to promote bowel movements and increase serum magnesium levels. Used for Constipation, Magnesium deficiency.
At a glance
| Generic name | Mg Oxide |
|---|---|
| Also known as | (Mg®, 21st Century®) |
| Sponsor | Shiraz University of Medical Sciences |
| Drug class | Osmotic laxative; magnesium supplement |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology; Nutritional supplementation |
| Phase | FDA-approved |
Mechanism of action
Magnesium oxide is poorly absorbed in the gastrointestinal tract and exerts an osmotic effect by retaining water in the intestinal lumen, thereby softening stool and promoting defecation. Additionally, the small fraction that is absorbed serves to replenish magnesium stores in the body, which is essential for numerous enzymatic and physiological functions including muscle and nerve function.
Approved indications
- Constipation
- Magnesium deficiency
Common side effects
- Diarrhea
- Abdominal cramping
- Nausea
- Hypermagnesemia (in renal impairment)
Key clinical trials
- Choline Supplementation and Cardiovascular Health (NA)
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Short Term Choline and Cardiovascular Health (NA)
- Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer (PHASE3)
- In Vivo Characterization of Inflammation With Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging (PHASE1)
- Nitric Oxide (NO) and Endothelial Dysfunction in Women With PTSD (NA)
- Investigating the Pharmacokinetics of Tafenoquine in Healthy Papua New Guinean Children (PHASE4)
- Postpartum 8-aminoquinoline Breast Milk Study (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Mg Oxide CI brief — competitive landscape report
- Mg Oxide updates RSS · CI watch RSS
- Shiraz University of Medical Sciences portfolio CI