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Metronidazole Tablet
Metronidazole Tablet is a Nitroimidazole antibiotic Small molecule drug developed by Appili Therapeutics Inc.. It is currently FDA-approved for Anaerobic bacterial infections (intra-abdominal, gynecological, respiratory), Parasitic infections (giardiasis, trichomoniasis, amebiasis), Bacterial vaginosis. Also known as: Flagyl, Metrogel, Revomet gel, No other Names.
Metronidazole is a nitroimidazole antibiotic that disrupts bacterial and parasitic DNA by generating reactive oxygen species after being reduced in anaerobic environments.
Metronidazole Tablet is a small molecule that inhibits DNA, classified as an inhibitor. It is used to treat various conditions, including Colorectal Cancer Stage II and III, Liver Abscess, Necrotic Primary Molars, and Surgical Site Infections, among others.
At a glance
| Generic name | Metronidazole Tablet |
|---|---|
| Also known as | Flagyl, Metrogel, Revomet gel, No other Names, Metro Gel |
| Sponsor | Appili Therapeutics Inc. |
| Drug class | Nitroimidazole antibiotic |
| Target | Bacterial and parasitic DNA |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Metronidazole is activated by anaerobic organisms and protozoans through reduction of its nitro group, generating cytotoxic free radicals that damage DNA and inhibit nucleic acid synthesis. This mechanism makes it effective against anaerobic bacteria and certain parasites while having minimal activity against aerobic organisms. The drug has been widely used for over 50 years to treat infections caused by anaerobic bacteria and parasites such as Giardia and Trichomonas.
Approved indications
- Anaerobic bacterial infections (intra-abdominal, gynecological, respiratory)
- Parasitic infections (giardiasis, trichomoniasis, amebiasis)
- Bacterial vaginosis
- Clostridioides difficile infection
- Helicobacter pylori infection (as part of combination therapy)
Common side effects
- Metallic taste
- Nausea
- Headache
- Diarrhea
- Peripheral neuropathy (with prolonged use)
- Disulfiram-like reaction with alcohol
Key clinical trials
- APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis) (PHASE2)
- The LISA (Lactoferrin InStead of Antibiotics/Antifungals) Feasibility Study (NA)
- Chlorhexidine and/or Metronidazole Plus FB301 Pre-treatment Trial (PHASE2)
- Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control (PHASE4)
- Investigating the Cholinergic Contribution to Gait Dysfunction in Parkinson's Disease (PHASE2)
- Hospital and Home Rehabilitation Based on Social Care Robotics and Artificial Intelligence for Pediatric Patients (NA)
- Tislelizumab With Fruquintinib, Metronidazole, in Mismatch Repair-proficient or Microsatellite Stability, Advanced Colorectal Cancer: a Multicenter, Single Arm, Clinical Trial (PHASE2)
- A Comparison of Recovery After Impacted Wisdom Tooth Removal (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Metronidazole Tablet CI brief — competitive landscape report
- Metronidazole Tablet updates RSS · CI watch RSS
- Appili Therapeutics Inc. portfolio CI
Frequently asked questions about Metronidazole Tablet
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Related
- Drug class: All Nitroimidazole antibiotic drugs
- Target: All drugs targeting Bacterial and parasitic DNA
- Manufacturer: Appili Therapeutics Inc. — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Anaerobic bacterial infections (intra-abdominal, gynecological, respiratory)
- Indication: Drugs for Parasitic infections (giardiasis, trichomoniasis, amebiasis)
- Indication: Drugs for Bacterial vaginosis
- Also known as: Flagyl, Metrogel, Revomet gel, No other Names, Metro Gel
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing