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Metronidazole Suppositories
Metronidazole is a nitroimidazole antibiotic that disrupts bacterial and protozoal DNA by generating reactive oxygen species after reduction of its nitro group.
Metronidazole is a nitroimidazole antibiotic that disrupts bacterial and protozoal DNA by generating reactive oxygen species after reduction of its nitro group. Used for Anaerobic bacterial infections of the colon and rectum, Protozoal infections (e.g., trichomoniasis, amebiasis), Bacterial vaginosis (local treatment).
At a glance
| Generic name | Metronidazole Suppositories |
|---|---|
| Sponsor | Dongfang Hospital Beijing University of Chinese Medicine |
| Drug class | Nitroimidazole antibiotic |
| Target | Bacterial/protozoal DNA |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Metronidazole is reduced by anaerobic organisms and protozoa to form reactive intermediates that damage DNA and inhibit nucleic acid synthesis, leading to cell death. It is effective against anaerobic bacteria and certain parasites including Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia. The suppository formulation delivers the drug locally to the vaginal or rectal mucosa for topical antimicrobial effect.
Approved indications
- Vaginal trichomoniasis
- Bacterial vaginosis
- Anaerobic bacterial infections (rectal/vaginal)
- Protozoal infections (Entamoeba, Giardia)
Common side effects
- Vaginal irritation or burning
- Metallic taste (systemic absorption)
- Allergic reactions
- Headache
Key clinical trials
- The LISA (Lactoferrin InStead of Antibiotics/Antifungals) Feasibility Study (NA)
- A Prospective, Randomized Controlled Study of the Probiotics as Adjuvant Treatment for Bacterial Vaginosis (PHASE4)
- Optimization of Bacterial Vaginosis Treatment in Women of Reproductive Age (PHASE4)
- Levofloxacin Plus Metronidazole Suppositories Versus Levofloxacin Co-administered with Metronidazole Tablets in Chronic Endometritis (NA)
- Effects of LiveSpo X-secret in Supporting Treatment of Sexually Transmitted Diseases (NA)
- Probiotics as Adjuvant Treatment for Bacterial Vaginosis (PHASE4)
- Oral Metronidazole With Lactobacillus Vaginal Suppositories to Prevent Recurrence of Bacterial Vaginosis (PHASE4)
- Treatment of Giardia Lamblia Infections in Children (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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