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"Metronidazole" and "Lactobacillus"
Metronidazole kills anaerobic bacteria and protozoa by damaging their DNA, while Lactobacillus restores beneficial gut flora to prevent dysbiosis-related complications.
Metronidazole kills anaerobic bacteria and protozoa by damaging their DNA, while Lactobacillus restores beneficial gut flora to prevent dysbiosis-related complications. Used for Bacterial vaginosis, Anaerobic bacterial infections, Antibiotic-associated diarrhea prevention.
At a glance
| Generic name | "Metronidazole" and "Lactobacillus" |
|---|---|
| Sponsor | Peking University Shenzhen Hospital |
| Drug class | Antibiotic + Probiotic combination |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Metronidazole is a nitroimidazole antibiotic that generates reactive oxygen species in anaerobic organisms, causing DNA strand breaks and cell death. Lactobacillus is a probiotic that repopulates the intestinal microbiome with beneficial bacteria, reducing overgrowth of pathogenic organisms and restoring normal gut flora balance. This combination approach treats infections while mitigating antibiotic-associated dysbiosis.
Approved indications
- Bacterial vaginosis
- Anaerobic bacterial infections
- Antibiotic-associated diarrhea prevention
- Parasitic infections (Giardia, Entamoeba)
Common side effects
- Metallic taste
- Nausea
- Headache
- Abdominal discomfort
- Peripheral neuropathy (with prolonged use)
Key clinical trials
- Live Double Combined Lactobacillus Capsule for Vaginal Use（IIa） (PHASE2)
- Evaluation of the Medical Device Vagitab - T as Adjuvant Therapy in Patients With Bacterial Vaginosis. (NA)
- Vaginal lIve Biotherapeutic RANdomized Trial (EARLY_PHASE1)
- To Evaluate the Effects of Systemic Probiotics & Antibiotics and Local Application of Antibiotics As an Adjuvant to NSPT (NA)
- Oral Probiotics for the Treatment and Prevention of Vulvovaginal Infections in Pregnancy - Double-blind, Randomized, Placebo-controlled Study (NA)
- Probiotic Efficacy in Postmenopausal Women with Bacterial Vaginosis (NA)
- The Efficacy of 10-day and 14-day Bismuth-based Quadruple Therapy in First-line H. Pylori Eradication (PHASE4)
- Microbiota Implementation to Reduce Anastomotic Colorectal Leaks (MIRACLe)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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