Last reviewed 2026-04-20 · How we verify

Metronidazole 1 g Intravenous

Metronidazole 1 g Intravenous is an antibiotic used primarily for the treatment of anaerobic bacterial infections and certain protozoal infections. It is administered intravenously in hospital settings. The drug is not FDA-approved but is widely used off-label. Common side effects include nausea, metallic taste, and headache. Metronidazole should be used with caution in patients with liver disease and during pregnancy. The drug has a broad spectrum of activity against anaerobes and is effective in treating conditions such as abdominal infections and pelvic inflammatory disease.

At a glance

Approved indications

No approved indications tracked.

Common side effects

No common side effects on file.

Drug interactions

• Disulfiram: Increased risk of disulfiram-like reactions
• Warfarin: Enhanced anticoagulant effect
• Lithium: Increased lithium levels
• Phenytoin: Decreased phenytoin clearance

Key clinical trials

• Comparing Oral Versus Parenteral Antimicrobial Therapy (PHASE4)
• Per Oral Versus Intravenous Postoperative Antibiotics After Surgery for Complicated Appendicitis. (NA)
• Study to Assess Efficacy and Safety of PF-06947386 in Japanese Adult Patients With Complicated Intra-abdominal Infection (PHASE3)
• Acute Appendicitis: Active Observation With and Without Antibiotics (PHASE4)
• Preoperative Oral Antibiotics With vs Without Mechanical Bowel Preparation to Reduce Surgical Site Infections Following Colonic Resection: an International Randomized Controlled Trial. (PHASE4)
• Patients Response to Early Switch To Oral:Osteomyelitis Study (EARLY_PHASE1)
• Intravenous Versus Intravenous/Oral Antibiotics for Perforated Appendicitis (NA)
• Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis (NA)

Patents

Primary sources

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