What is Deseril used for?

Deseril is indicated for Migraine Prevention.

What development phase is Deseril in?

Deseril is FDA-approved (marketed).

What is the generic name of Deseril?

METHYSERGIDE is the generic (nonproprietary) name of Deseril.

Last reviewed 2026-04-20 · How we verify

Deseril (METHYSERGIDE)

FDA-approved approved Small molecule Quality 30/100

Methysergide (Deseril) is a marketed drug used for migraine prevention, with a key composition patent expiring in 2028. Its mechanism of blocking serotonin receptors sets it apart in the same class as dihydroergotamine and ergotamine, where it competes with a patent-protected dihydroergotamine and off-patent ergotamine generics. The primary risk is the potential loss of market share to the off-patent ergotamine generics, which may erode Methysergide's market position post-2028 patent expiry.

At a glance

Generic name	METHYSERGIDE
Drug class	methysergide
Target	5-hydroxytryptamine receptor 2A
Modality	Small molecule
Therapeutic area	Neuroscience
Phase	FDA-approved
First approval	1962

Approved indications

Migraine Prevention

Common side effects

No common side effects on file.

Drug interactions

conivaptan
delavirdine
mibefradil
nefazodone
nelfinavir

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
FDA label	Mechanism, indications, dosing, boxed warnings, drug interactions

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Deseril CI brief — competitive landscape report
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