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methylprednisolone PO

Rennes University Hospital · FDA-approved active Small molecule

methylprednisolone PO is a Corticosteroid (glucocorticoid) Small molecule drug developed by Rennes University Hospital. It is currently FDA-approved for Inflammatory and autoimmune disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus), Allergic reactions and asthma exacerbations, Adrenal insufficiency.

Methylprednisolone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.

Methylprednisolone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Inflammatory and autoimmune disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus), Allergic reactions and asthma exacerbations, Adrenal insufficiency.

At a glance

Generic namemethylprednisolone PO
SponsorRennes University Hospital
Drug classCorticosteroid (glucocorticoid)
TargetGlucocorticoid receptor (GR)
ModalitySmall molecule
Therapeutic areaImmunology / Rheumatology / General anti-inflammatory
PhaseFDA-approved

Mechanism of action

Methylprednisolone is a synthetic glucocorticoid that exerts its anti-inflammatory and immunosuppressive effects by binding to intracellular glucocorticoid receptors, translocating to the nucleus, and modulating gene expression. This leads to decreased production of inflammatory mediators (cytokines, chemokines, adhesion molecules) and reduced immune cell activation and proliferation. It is commonly used orally (PO) for a wide range of inflammatory and autoimmune conditions.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about methylprednisolone PO

What is methylprednisolone PO?

methylprednisolone PO is a Corticosteroid (glucocorticoid) drug developed by Rennes University Hospital, indicated for Inflammatory and autoimmune disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus), Allergic reactions and asthma exacerbations, Adrenal insufficiency.

How does methylprednisolone PO work?

Methylprednisolone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.

What is methylprednisolone PO used for?

methylprednisolone PO is indicated for Inflammatory and autoimmune disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus), Allergic reactions and asthma exacerbations, Adrenal insufficiency, Certain hematologic malignancies and lymphomas, Organ transplant rejection prophylaxis.

Who makes methylprednisolone PO?

methylprednisolone PO is developed and marketed by Rennes University Hospital (see full Rennes University Hospital pipeline at /company/rennes-university-hospital).

What drug class is methylprednisolone PO in?

methylprednisolone PO belongs to the Corticosteroid (glucocorticoid) class. See all Corticosteroid (glucocorticoid) drugs at /class/corticosteroid-glucocorticoid.

What development phase is methylprednisolone PO in?

methylprednisolone PO is FDA-approved (marketed).

What are the side effects of methylprednisolone PO?

Common side effects of methylprednisolone PO include Hyperglycemia / glucose intolerance, Hypertension, Insomnia and mood changes, Increased infection risk, Osteoporosis (with chronic use), Gastrointestinal upset.

What does methylprednisolone PO target?

methylprednisolone PO targets Glucocorticoid receptor (GR) and is a Corticosteroid (glucocorticoid).

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