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Methylprednisolone and IVIG
Methylprednisolone and IVIG is a Combination immunosuppressant and immunomodulator Small molecule drug developed by The Hospital for Sick Children. It is currently in Phase 3 development for Autoimmune or inflammatory conditions in pediatric patients (specific indication context-dependent on trial design). Also known as: Solumedrol.
Methylprednisolone suppresses immune inflammation via glucocorticoid receptor signaling, while IVIG provides immunomodulation through Fc receptor engagement and anti-inflammatory pathways.
Methylprednisolone suppresses immune inflammation via glucocorticoid receptor signaling, while IVIG provides immunomodulation through Fc receptor engagement and anti-inflammatory pathways. Used for Autoimmune or inflammatory conditions in pediatric patients (specific indication context-dependent on trial design).
At a glance
| Generic name | Methylprednisolone and IVIG |
|---|---|
| Also known as | Solumedrol |
| Sponsor | The Hospital for Sick Children |
| Drug class | Combination immunosuppressant and immunomodulator |
| Target | Glucocorticoid receptor (methylprednisolone); Fc receptors and complement (IVIG) |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | Phase 3 |
Mechanism of action
Methylprednisolone is a corticosteroid that reduces inflammatory cytokine production and immune cell activation. IVIG (intravenous immunoglobulin) modulates immune responses through multiple mechanisms including Fc receptor blockade, complement inhibition, and anti-inflammatory signaling. Together, this combination targets both innate and adaptive immune dysregulation.
Approved indications
- Autoimmune or inflammatory conditions in pediatric patients (specific indication context-dependent on trial design)
Common side effects
- Infection (opportunistic or bacterial)
- Hyperglycemia
- Hypertension
- Headache
- Infusion reactions
- Immunosuppression-related complications
Key clinical trials
- Intravenous Immunoglobulin for the Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis (PHASE3)
- Therapy in the Acute Phase of NMOSD: A Multicenter Prospective Real-World Study (PHASE4)
- Infliximab and Intravenous Immunoglobulin Therapy in Treating Patients With Steroid-Refractory Pneumonitis (PHASE2)
- Autoantibody Reduction for Acute Exacerbations of Idiopathic Pulmonary Fibrosis (PHASE2)
- Stem Cell Transplantation in Crohn's Disease (PHASE1, PHASE2)
- The Effect and Safety Profile of Thymoglobulin® in Primary Cardiac Transplant Recipients (PHASE2)
- Efficacy of Immunoglobulin Plus Prednisolone in Reducing Coronary Artery Lesion in Patients With Kawasaki Disease (PHASE3)
- Intravenous Immunoglobulin and Prednisolone for RPL After ART. (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Methylprednisolone and IVIG CI brief — competitive landscape report
- Methylprednisolone and IVIG updates RSS · CI watch RSS
- The Hospital for Sick Children portfolio CI
Frequently asked questions about Methylprednisolone and IVIG
What is Methylprednisolone and IVIG?
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What does Methylprednisolone and IVIG target?
Related
- Drug class: All Combination immunosuppressant and immunomodulator drugs
- Target: All drugs targeting Glucocorticoid receptor (methylprednisolone); Fc receptors and complement (IVIG)
- Manufacturer: The Hospital for Sick Children — full pipeline
- Therapeutic area: All drugs in Immunology
- Indication: Drugs for Autoimmune or inflammatory conditions in pediatric patients (specific indication context-dependent on trial design)
- Also known as: Solumedrol
- Compare: Methylprednisolone and IVIG vs similar drugs
- Pricing: Methylprednisolone and IVIG cost, discount & access