Last reviewed 2026-04-23 · How we verify

methylphenidate hydrochloride extended-release tablets

Methylphenidate hydrochloride is a central nervous system stimulant that works by increasing the levels of dopamine and norepinephrine in the brain.

Methylphenidate hydrochloride is a central nervous system stimulant that works by increasing the levels of dopamine and norepinephrine in the brain. Used for Attention deficit hyperactivity disorder (ADHD).

At a glance

Mechanism of action

It does this by inhibiting the reuptake of these neurotransmitters, allowing them to remain in the synaptic cleft for a longer period and increasing their activity. This leads to increased alertness, attention, and energy.

Approved indications

• Attention deficit hyperactivity disorder (ADHD)

Common side effects

• Nausea
• Headache
• Insomnia
• Dry mouth
• Anxiety

Key clinical trials

• A Trial to Assess How Centanafadine Interacts With Stimulants in the Body (PHASE1)
• Neurofeedback-Based Digital Therapeutics for the Diagnosis and Treatment of ADHD in Children. (NA)
• Lisdexamphetamine Vs Methylphenidate for Pediatric Patients with ADHD and Type 1 Diabetes (PHASE2)
• Real-World Evidence of Duration of Effect of Adhansia XR (Extended-Release) for Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) (PHASE4)
• A Pilot of Methylphenidate in Mild Cognitive Impairment and Dementia Participants. (PHASE4)
• A Drug Interaction Study of SPD503 and Concerta Administered Alone and In Combination in Normal Healthy Volunteers (PHASE1)
• CTx-1301 Comparative Bioavailability Study (PHASE1, PHASE2)
• Guanfacine for the Treatment of Hyperactivity in Pervasive Developmental Disorder (PHASE4)

Primary sources

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