Last reviewed · How we verify
Metformin ER
At a glance
| Generic name | Metformin ER |
|---|---|
| Also known as | Metformin Extended Release, Riomet, Glucophage XR®, ER Metformin Hydrochloride, Extended-release Metformin Hydrochloride |
| Sponsor | Matthew Neal MD |
| Modality | Small molecule |
| Phase | FDA-approved |
Approved indications
Common side effects
- Diarrhea
- Nausea/Vomiting
- Flatulence
- Asthenia
- Indigestion
- Abdominal Discomfort
- Headache
- Abdominal Pain
- Constipation
- Distention Abdomen
- Dyspepsia/Heartburn
- Dizziness
Serious adverse events
- Lactic Acidosis
- Cholestatic Liver Injury
- Hepatocellular Liver Injury
- Mixed Hepatocellular Liver Injury
- Vitamin B12 Deficiency
Key clinical trials
- Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion (PHASE2)
- Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma (PHASE2)
- Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy (PHASE3)
- Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer (PHASE2)
- Metformin and Nightly Fasting in Women With Early Breast Cancer (PHASE2)
- Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients (PHASE2)
- Managing Chronic Tendon Pain by Metformin (PHASE1)
- An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Metformin ER CI brief — competitive landscape report
- Metformin ER updates RSS · CI watch RSS
- Matthew Neal MD portfolio CI