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Metformin and Insulin sc
Metformin works by decreasing glucose production in the liver and increasing insulin sensitivity, while insulin sc works by replacing or supplementing the body's natural insulin.
Metformin works by decreasing glucose production in the liver and increasing insulin sensitivity, while insulin sc works by replacing or supplementing the body's natural insulin. Used for Type 2 diabetes.
At a glance
| Generic name | Metformin and Insulin sc |
|---|---|
| Also known as | Siofor, Lantus |
| Sponsor | Institut für Pharmakologie und Präventive Medizin |
| Drug class | SGLT2 inhibitor and insulin |
| Modality | Small molecule |
| Therapeutic area | Diabetes |
| Phase | Phase 3 |
Mechanism of action
Metformin inhibits the enzyme complex mitochondrial glycerophosphate dehydrogenase, which is involved in gluconeogenesis. Insulin sc, on the other hand, mimics the action of the body's natural insulin, facilitating glucose uptake in cells and suppressing glucose production in the liver.
Approved indications
- Type 2 diabetes
Common side effects
- Hypoglycemia
- Nausea
- Diarrhea
- Abdominal pain
- Headache
Key clinical trials
- Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3) (PHASE3)
- A Study to Evaluate Tirzepatide (LY3298176) in Pediatric and Adolescent Participants With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin or Basal Insulin or Both (PHASE3)
- iGlarLixi vs IDegAsp in Chinese Participants After OAD(s) (PHASE3)
- A Study of Tirzepatide (LY3298176) Versus Insulin Lispro (U100) in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or Without Metformin (PHASE3)
- Remission Evaluation of a Metabolic Intervention for Type 2 Diabetes With IDegLira (PHASE3)
- Liraglutide and Metformin Combination on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With PCOS, Obesity and Infertility (PHASE3)
- A Study of Dulaglutide (LY2189265) in Chinese Participants With Type 2 Diabetes (PHASE3)
- A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes on Metformin With or Without Sulfonylurea (SURPASS-AP-Combo) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Metformin and Insulin sc CI brief — competitive landscape report
- Metformin and Insulin sc updates RSS · CI watch RSS
- Institut für Pharmakologie und Präventive Medizin portfolio CI