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Metformin / alogliptin Oral Product
Metformin / alogliptin Oral Product is a Biguanide / DPP-4 inhibitor combination Small molecule drug developed by University of Catanzaro. It is currently FDA-approved for Type 2 diabetes mellitus.
Metformin reduces hepatic glucose production and improves insulin sensitivity, while alogliptin inhibits DPP-4 to increase incretin levels and stimulate insulin secretion in response to glucose.
Metformin reduces hepatic glucose production and improves insulin sensitivity, while alogliptin inhibits DPP-4 to increase incretin levels and stimulate insulin secretion in response to glucose. Used for Type 2 diabetes mellitus.
At a glance
| Generic name | Metformin / alogliptin Oral Product |
|---|---|
| Sponsor | University of Catanzaro |
| Drug class | Biguanide / DPP-4 inhibitor combination |
| Target | Metformin: mitochondrial glycerophosphate dehydrogenase; Alogliptin: dipeptidyl peptidase-4 (DPP-4) |
| Modality | Small molecule |
| Therapeutic area | Diabetes |
| Phase | FDA-approved |
Mechanism of action
Metformin is a biguanide that decreases gluconeogenesis and enhances peripheral glucose uptake, primarily in muscle and adipose tissue. Alogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that prevents the degradation of GLP-1 and GIP, thereby prolonging their action to stimulate glucose-dependent insulin secretion and suppress glucagon. Together, they provide complementary mechanisms for glycemic control in type 2 diabetes.
Approved indications
- Type 2 diabetes mellitus
Common side effects
- Gastrointestinal disturbance (nausea, diarrhea, abdominal discomfort)
- Hypoglycemia
- Headache
- Nasopharyngitis
- Lactic acidosis (rare, metformin-related)
Key clinical trials
- A Study to Evaluate the Effect of add-on Pioglitazone or Dapagliflozin in Participants With Type 2 Diabetes Mellitus Inadequately Controlled by DPP-4 Inhibitor and Metformin Therapy (PHASE4)
- Comparative Study to Evaluate Efficacy and Safety When Metformin Hydrochloride 500 mg Once Daily is Added on to SYR-322 25 mg in Type 2 Diabetic Patients With Inadequate Glycemic Control Despite Treatment With SYR-322 25 mg in Addition to Diet and Exercise Therapy (PHASE3)
- Specified Drug-Use Survey of Alogliptin and Metformin Hydrochloride Combination Tablets "Survey on Long-term Use in Type 2 Diabetes Mellitus Patients With Renal or Hepatic Impairment or Advanced Age"
- Phase 3 Alogliptin Pediatric Study (PHASE3)
- Efficacy and Safety of Alogliptin vs. Acarbose in Chinese Type 2 Diabetes Mellitus (T2DM) Patients With High CV Risk or CHD Treated With Aspirin and Inadequately Controlled With Metformin Monotherapy or Drug Naive (PHASE4)
- Anti-inflammatory Status in DM2 Treated Patients (PHASE4)
- Non-Interventional Study of the Use of Alogliptin and Alogliptin Fixed-Dose Combinations With Pioglitazone and With Metformin in Standard Clinical Practice
- Roflumilast Plus Alogliptin Proof-of-Mechanism Study in Type2 Diabetes (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Metformin / alogliptin Oral Product CI brief — competitive landscape report
- Metformin / alogliptin Oral Product updates RSS · CI watch RSS
- University of Catanzaro portfolio CI
Frequently asked questions about Metformin / alogliptin Oral Product
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Related
- Drug class: All Biguanide / DPP-4 inhibitor combination drugs
- Target: All drugs targeting Metformin: mitochondrial glycerophosphate dehydrogenase; Alogliptin: dipeptidyl peptidase-4 (DPP-4)
- Manufacturer: University of Catanzaro — full pipeline
- Therapeutic area: All drugs in Diabetes
- Indication: Drugs for Type 2 diabetes mellitus
- Compare: Metformin / alogliptin Oral Product vs similar drugs
- Pricing: Metformin / alogliptin Oral Product cost, discount & access