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Metamizole Sodium
Metamizole sodium inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes, reducing pain, fever, and inflammation.
Metamizole sodium inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes, reducing pain, fever, and inflammation. Used for Acute pain (postoperative, traumatic, or other acute pain conditions), Fever, Chronic pain conditions.
At a glance
| Generic name | Metamizole Sodium |
|---|---|
| Also known as | Metamizole |
| Sponsor | Insel Gruppe AG, University Hospital Bern |
| Drug class | Non-steroidal anti-inflammatory drug (NSAID) |
| Target | Cyclooxygenase (COX-1 and COX-2) |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Fever, Inflammation |
| Phase | FDA-approved |
Mechanism of action
Metamizole is a non-selective COX inhibitor that decreases prostaglandin production, leading to analgesic, antipyretic, and anti-inflammatory effects. It is a prodrug that is rapidly metabolized to active metabolites in the body. Unlike some other NSAIDs, it has a relatively favorable safety profile in terms of gastrointestinal effects, though agranulocytosis remains a rare but serious concern.
Approved indications
- Acute pain (postoperative, traumatic, or other acute pain conditions)
- Fever
- Chronic pain conditions
Common side effects
- Agranulocytosis
- Gastrointestinal upset
- Allergic reactions
- Rash
Key clinical trials
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Non-Steroidal Anti-Inflammatory Drugs in Acute Myocarditis (PHASE3)
- Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (PHASE4)
- Study Protocol: Impact of Metamizole (Optalgin®) on Anti-Xa Concentrations in Oncology Patients Receiving DOACs (NA)
- Program to Avoid NSAIDs in Patients With Advanced Chronic Liver Disease (NA)
- Optimal Timing of Endoscopic Intervention in the Treatment of Chronic Pancreatitis. (NA)
- Comparison of the Effectiveness of Paracetamol With Ibuprofen or Paracetamol With Metamizole in Treating Pain in Acute Pancreatitis in Children (PHASE4)
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Metamizole Sodium CI brief — competitive landscape report
- Metamizole Sodium updates RSS · CI watch RSS
- Insel Gruppe AG, University Hospital Bern portfolio CI