Last reviewed · How we verify
Mepivacaine Injection
Mepivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses.
Mepivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. Used for Local anesthesia for infiltration, nerve block, and epidural anesthesia, Dental anesthesia.
At a glance
| Generic name | Mepivacaine Injection |
|---|---|
| Also known as | MEPIVACAINA CLORIDRATO, Prilocaine |
| Sponsor | Nova Scotia Health Authority |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Mepivacaine reversibly inhibits sodium influx into nerve fibers by binding to sodium channels from the intracellular side, thereby stabilizing the neuronal membrane and raising the threshold for electrical excitability. This action prevents depolarization and conduction of action potentials in sensory and motor nerves, producing localized anesthesia. The drug is an amide-type local anesthetic with intermediate duration of action.
Approved indications
- Local and regional anesthesia for dental procedures
- Local and regional anesthesia for minor surgical procedures
- Infiltration anesthesia
- Nerve block anesthesia
Common side effects
- Paresthesia
- Dizziness
- Headache
- Nervousness
- Allergic reactions (rare)
- Methemoglobinemia (rare)
Key clinical trials
- Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension (PHASE4)
- Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty (PHASE4)
- Oct Angiography Changes After Local Anesthesia in Cataract Surgery (NA)
- PENG Block + LIA For Endoprosthesis Surgery With Anterior Approach (NA)
- Platelet-Rich Plasma Versus Home-Based Exercise for Partial-Thickness Supraspinatus Tears (NA)
- Assessment of Anesthetic Efficacy and Hemodynamic Stability of Two LA Drugs for Hypertensive Patients (NA)
- Stellate Ganglion Block for COVID-induced Parosmia (PHASE2)
- Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Mepivacaine Injection CI brief — competitive landscape report
- Mepivacaine Injection updates RSS · CI watch RSS
- Nova Scotia Health Authority portfolio CI