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Mepivacaine 1%
Mepivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses.
Mepivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. Used for Local and regional anesthesia for dental procedures, Local and regional anesthesia for minor surgical procedures, Infiltration anesthesia.
At a glance
| Generic name | Mepivacaine 1% |
|---|---|
| Sponsor | ASST Gaetano Pini-CTO |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Mepivacaine reversibly inhibits sodium influx into nerve fibers by binding to sodium channels from the inside of the cell membrane. This prevents depolarization and action potential generation, thereby blocking sensory and motor nerve conduction in a dose-dependent manner. The drug is amide-type local anesthetic with intermediate duration of action.
Approved indications
- Local and regional anesthesia for infiltration, nerve block, and epidural anesthesia
- Dental anesthesia
Common side effects
- Paresthesia
- Dizziness
- Headache
- Nervousness
- Methemoglobinemia (rare, dose-dependent)
Key clinical trials
- Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension (PHASE4)
- Discomfort Following Oral Biopsy Comparing Laser and Punch Biopsy (NA)
- Stellate Ganglion Block for COVID-19-Induced Olfactory Dysfunction (PHASE1, PHASE2)
- Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty (PHASE4)
- PENG Block + LIA For Endoprosthesis Surgery With Anterior Approach (NA)
- A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours. (NA)
- Platelet-Rich Plasma Versus Home-Based Exercise for Partial-Thickness Supraspinatus Tears (NA)
- Assessment of Anesthetic Efficacy and Hemodynamic Stability of Two LA Drugs for Hypertensive Patients (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |