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medical nutrition therapy + metformin
medical nutrition therapy + metformin is a Combination therapy: dietary intervention + biguanide antidiabetic Small molecule drug developed by Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes. It is currently FDA-approved for Gestational diabetes mellitus (likely, given Instituto Nacional de Perinatologia focus), Type 2 diabetes management.
Medical nutrition therapy combined with metformin reduces blood glucose through dietary management and insulin sensitization, respectively.
Medical nutrition therapy combined with metformin reduces blood glucose through dietary management and insulin sensitization, respectively. Used for Gestational diabetes mellitus (likely, given Instituto Nacional de Perinatologia focus), Type 2 diabetes management.
At a glance
| Generic name | medical nutrition therapy + metformin |
|---|---|
| Sponsor | Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes |
| Drug class | Combination therapy: dietary intervention + biguanide antidiabetic |
| Target | AMP-activated protein kinase (AMPK) and hepatic glucose metabolism (metformin component) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Diabetes |
| Phase | FDA-approved |
Mechanism of action
Medical nutrition therapy (MNT) involves structured dietary intervention to improve metabolic control and weight management. Metformin, a biguanide, decreases hepatic glucose production and improves peripheral insulin sensitivity. Together, they address both nutritional and pharmacological aspects of glucose homeostasis.
Approved indications
- Gestational diabetes mellitus (likely, given Instituto Nacional de Perinatologia focus)
- Type 2 diabetes management
Common side effects
- Gastrointestinal disturbance (nausea, diarrhea, abdominal discomfort)
- Metallic taste
- Vitamin B12 deficiency (with long-term metformin use)
- Lactic acidosis (rare)
Key clinical trials
- Metformin vs Inositol vs Diet vs Combination Therapy in PCOS (NA)
- Effect of Conventional vs Intensive Management on Gestational Diabetes and Maternal Fetal Outcomes (NA)
- A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging (PHASE2)
- Paxalisib With a High Fat, Low Carb Diet and Metformin for Glioblastoma (PHASE2)
- Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF) (PHASE4)
- Heterogeneity of Diabetes: Integrated Muli-Omics to Identify Physiologic Subphenotypes and Evaluate Targeted Prevention (PHASE4)
- Personalised Medicine in Pre-diabetes and Early Type 2 Diabetes (NA)
- Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- medical nutrition therapy + metformin CI brief — competitive landscape report
- medical nutrition therapy + metformin updates RSS · CI watch RSS
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes portfolio CI
Frequently asked questions about medical nutrition therapy + metformin
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Related
- Drug class: All Combination therapy: dietary intervention + biguanide antidiabetic drugs
- Target: All drugs targeting AMP-activated protein kinase (AMPK) and hepatic glucose metabolism (metformin component)
- Manufacturer: Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes — full pipeline
- Therapeutic area: All drugs in Endocrinology / Diabetes
- Indication: Drugs for Gestational diabetes mellitus (likely, given Instituto Nacional de Perinatologia focus)
- Indication: Drugs for Type 2 diabetes management
- Compare: medical nutrition therapy + metformin vs similar drugs
- Pricing: medical nutrition therapy + metformin cost, discount & access