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Mechanical Bowel Preparation
Mechanical Bowel Preparation is a Bowel cleanser / Laxative preparation Small molecule drug developed by Helsinki University Central Hospital. It is currently FDA-approved for Bowel preparation prior to colonoscopy, Bowel preparation prior to colorectal surgery, Bowel preparation prior to other gastrointestinal procedures. Also known as: Nulitelly, polyethylene glycol.
Mechanical bowel preparation physically clears the colon of fecal matter and debris through osmotic and/or mechanical action to prepare the bowel for diagnostic or surgical procedures.
Mechanical bowel preparation physically clears the colon of stool and debris through osmotic or stimulant action to prepare the bowel for endoscopic procedures. Used for Bowel preparation prior to colonoscopy, Bowel preparation prior to sigmoidoscopy, Bowel preparation prior to colorectal surgery.
At a glance
| Generic name | Mechanical Bowel Preparation |
|---|---|
| Also known as | Nulitelly, polyethylene glycol |
| Sponsor | Helsinki University Central Hospital |
| Drug class | Bowel cleanser / Laxative preparation |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Mechanical bowel preparation typically involves the administration of polyethylene glycol (PEG) solutions, sodium phosphate, or other osmotic agents that draw fluid into the intestinal lumen, increasing stool bulk and promoting evacuation. This non-pharmacological approach mechanically cleanses the colon without relying on systemic drug absorption, making it a standard preparatory procedure rather than a therapeutic drug in the traditional sense.
Approved indications
- Bowel preparation prior to colonoscopy
- Bowel preparation prior to colorectal surgery
- Bowel preparation prior to other gastrointestinal procedures
Common side effects
- Abdominal discomfort or cramping
- Nausea
- Vomiting
- Dehydration
- Electrolyte imbalance
Key clinical trials
- Acupuncture for Colorectal sUrgery Recovery Enhancement: A Randomized Controlled Trial Evaluating Gastrointestinal Functional Recovery After Minimally Invasive Resection (NA)
- Investigation of the Effect of Preoperative Bowel Cleansing on Postoperative Cognitive Impairment (NA)
- Mechanical Bowel Preparation With or Without Oral Antibiotics in Left Sided Colorectal Cancer Surgery (NA)
- Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery II (NA)
- Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery (PHASE4)
- GRECCAR 8: Primary Tumor Resection in Rectal Cancer With Unresectable Metastasis (PHASE3)
- Pediatric Colostomy Reversal: Traditional Care vs. Enhanced Recovery After Surgery (NA)
- Effect of Counseling and Education on Mechanical Bowel Preparation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Mechanical Bowel Preparation CI brief — competitive landscape report
- Mechanical Bowel Preparation updates RSS · CI watch RSS
- Helsinki University Central Hospital portfolio CI
Frequently asked questions about Mechanical Bowel Preparation
What is Mechanical Bowel Preparation?
How does Mechanical Bowel Preparation work?
What is Mechanical Bowel Preparation used for?
Who makes Mechanical Bowel Preparation?
Is Mechanical Bowel Preparation also known as anything else?
What drug class is Mechanical Bowel Preparation in?
What development phase is Mechanical Bowel Preparation in?
What are the side effects of Mechanical Bowel Preparation?
Related
- Drug class: All Bowel cleanser / Laxative preparation drugs
- Manufacturer: Helsinki University Central Hospital — full pipeline
- Therapeutic area: All drugs in Gastroenterology
- Indication: Drugs for Bowel preparation prior to colonoscopy
- Indication: Drugs for Bowel preparation prior to colorectal surgery
- Indication: Drugs for Bowel preparation prior to other gastrointestinal procedures
- Also known as: Nulitelly, polyethylene glycol
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing