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Measles and Rubella (MR)
The MR vaccine stimulates the immune system to produce antibodies and cellular immunity against measles and rubella viruses through live attenuated viral antigens.
The MR vaccine stimulates the immune system to produce antibodies and cellular immunity against measles and rubella viruses through live attenuated viral antigens. Used for Prevention of measles, Prevention of rubella.
At a glance
| Generic name | Measles and Rubella (MR) |
|---|---|
| Sponsor | International Centre for Diarrhoeal Disease Research, Bangladesh |
| Drug class | Live attenuated vaccine |
| Target | Measles virus and Rubella virus antigens |
| Modality | Biologic |
| Therapeutic area | Immunology / Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
The vaccine contains weakened (attenuated) strains of measles and rubella viruses that replicate in vaccinated individuals without causing disease. This triggers both humoral (antibody-mediated) and cell-mediated immune responses, providing protective immunity against natural infection with these viruses. The vaccine prevents viral replication and transmission in susceptible populations.
Approved indications
- Prevention of measles
- Prevention of rubella
Common side effects
- Fever
- Rash
- Local injection site reactions (pain, erythema, swelling)
- Arthralgia (more common in rubella component)
- Lymphadenopathy
Key clinical trials
- Strengthening HPV Immunization Through EPI Leveraged Delivery (PHASE2)
- A Study on the Immune Response and Safety of a Multicomponent Shigella Vaccine in Preventing Shigellosis in Infants (PHASE2)
- A Study on the Safety and Immune Responses to the GVGH altSonflex1-2-3 Vaccine Against Shigellosis in Adults, Children, and Infants (PHASE1)
- Infant Malaria Vaccine Schedule Optimization (PHASE2)
- Measles-Rubella Vaccine Immunogenicity at 6 and 9 Months of Age (PHASE4)
- A Study on the Immune Response and Safety of a Combined Measles, Mumps, Rubella, Chickenpox Vaccine Compared to a Marketed Combined Vaccine, Given to Healthy Children 4 to 6 Years of Age (PHASE2)
- Non-interference Study of MR and Yellow Fever Vaccines Among Bangladeshi Infants Aged 9-12 Months (PHASE3)
- A Study on the Safety, Reactogenicity, and Immune Response to the GVGH iNTS-GMMA Vaccine Against Invasive Nontyphoidal Salmonella in Adults, Children, and Infants (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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