Last reviewed · How we verify
Marketed Control
Metformin works by decreasing glucose production in the liver and increasing insulin sensitivity.
Metformin works by decreasing glucose production in the liver and increasing insulin sensitivity. Used for Type 2 diabetes.
At a glance
| Generic name | Marketed Control |
|---|---|
| Sponsor | Procter and Gamble |
| Drug class | Biguanide |
| Modality | Small molecule |
| Therapeutic area | Diabetes |
| Phase | Phase 3 |
Mechanism of action
Metformin acts by inhibiting the mitochondrial respiratory chain complex 1, which decreases hepatic glucose production and increases insulin sensitivity. This results in improved glycemic control in patients with type 2 diabetes.
Approved indications
- Type 2 diabetes
Common side effects
- Gastrointestinal upset
- Lactic acidosis
Key clinical trials
- Effects of 2-Aticyto Complex and D-Ribose on Pain and Clinical Course in Patients With Fibromyalgia (NA)
- A Clinical Study Assessing the Maximum Maxillary Bite Force When Using Three Denture Adhesives Compared to Using No-Adhesive (NA)
- A Phase I Study to Compare the Pharmacokinetic Characteristics, Safety, and Immunogenicity of HLX319 and EU-Phesgo®. (PHASE1)
- Ademetionine in Obstructive Hypertrophic Cardiomyopathy (PHASE2)
- Pilot Dispensing Study of Two Marketed Daily Disposable Multifocal Contact Lenses (NA)
- Moderate-intensity Statin vs. Individualized LDL-C Target-based Therapy in Older Adults With Type 2 Diabetes (iTARGET-Elderly Study) (NA)
- Comprehensive Multi-omics Characterization and Implications of Non-Pharmaceutical Dental Hygiene Product in a Randomized Controlled Large Population Study. (NA)
- Zoster Vaccine to Enhance Protection Against Zoster in Solid-organ Transplantation (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |