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Marcaine ½%
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local infiltration anesthesia, Peripheral nerve blocks, Regional anesthesia (epidural, spinal).
At a glance
| Generic name | Marcaine ½% |
|---|---|
| Sponsor | Randers Regional Hospital |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly inhibits sodium influx into nerve fibers by binding to sodium channels from the intracellular side, thereby stabilizing the neuronal membrane and preventing depolarization. This action is concentration-dependent and affects sensory nerves before motor nerves. The 0.5% formulation provides moderate anesthetic potency suitable for infiltration, nerve blocks, and regional anesthesia.
Approved indications
- Local infiltration anesthesia
- Peripheral nerve blocks
- Regional anesthesia procedures
- Epidural anesthesia
Common side effects
- Systemic toxicity (CNS: tremor, seizures)
- Systemic toxicity (cardiac: arrhythmias, hypotension)
- Local reactions at injection site
- Allergic reactions
Key clinical trials
- Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients" (NA)
- Repeated Bilateral Greater Occipital Nerve Blockade in Chronic Migraine and Chronic Tension-Type Headache (NA)
- Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block for Analgesia in Arthroscopic Shoulder Surgery (NA)
- Arthrosemid vs. Steroid for the Management Knee Osteoarthritis (PHASE4)
- Bilateral Cervical Plexus Block for Postoperative Pain After Thyroidectomy (NA)
- Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion (EARLY_PHASE1)
- mTLIP vs QIPB for Postoperative Analgesia in Lumbar Microdiscectomy Surgery (NA)
- Continuous Epidural With Dexmedetomidine Adjuvant in Gynecologic Laparotomy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Marcaine ½% CI brief — competitive landscape report
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