Last reviewed 2026-04-23 · How we verify

MAR

MAR is a medication that works by inhibiting the reuptake of norepinephrine, serotonin, and dopamine.

MAR is a medication that works by inhibiting the reuptake of norepinephrine, serotonin, and dopamine. Used for Major depressive disorder, Attention deficit hyperactivity disorder (ADHD).

At a glance

Mechanism of action

This action increases the levels of these neurotransmitters in the brain, which can help improve mood and reduce symptoms of depression. MAR is a norepinephrine-dopamine reuptake inhibitor (NDRIs), which is a class of medications that target multiple neurotransmitters to treat depression and other mood disorders.

Approved indications

• Major depressive disorder
• Attention deficit hyperactivity disorder (ADHD)

Common side effects

• Nausea
• Headache
• Dizziness
• Insomnia
• Dry mouth

Key clinical trials

• Individualised Endometrial Cancer Risk Stratification by Bayesian Prediction Model (ENDORISK), Optimizing Clinical Implementation (NA)
• Impact of COVID-19 Pandemic on Single-stage Laparoscopic Cholecystectomy and Laparoscopic Common Bile Duct Exploration Service
• Pharmacogenetic-Guided Antidepressant Treatment in Depression (NA)
• Influenza Vaccination, ACEI and ARB in the Evolution of SARS-CoV2 Infection
• Effect of Academic Detailing on Opioid Prescribing by Dentists to Adolescents and Young Adults (NA)
• Self-Efficacy and Academic Burnout Among Sports Science Undergraduates in Indonesia
• Risk of Hydroceles Following Pyeloplasty
• Characteristics and Outcomes of Patients Admitted to Swedish Intensive Care Units for COVID-19

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.