Last reviewed 2026-04-23 · How we verify

Mannitol cream

Mannitol cream acts as a topical osmotic agent that draws fluid from underlying tissues to reduce edema and inflammation in skin conditions.

Mannitol cream acts as a topical osmotic agent that draws fluid from underlying tissues to reduce edema and inflammation in skin conditions. Used for Dermatological condition under investigation (specific indication not publicly confirmed).

At a glance

Mechanism of action

Mannitol is a sugar alcohol that creates an osmotic gradient when applied topically, pulling interstitial fluid toward the skin surface and reducing local swelling. This mechanism may help reduce inflammation, improve wound healing, and provide symptomatic relief in dermatological conditions. The exact therapeutic target in this Phase 3 formulation requires clarification from clinical trial data.

Approved indications

• Dermatological condition under investigation (specific indication not publicly confirmed)

Common side effects

• Local skin irritation
• Burning or stinging at application site

Key clinical trials

• A Study to Evaluate the Effects for Midface Improvement When Pairing a Biostimulator with a Skincare Regimen (NA)
• Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy (PHASE1, PHASE2)
• Mannitol Cream for Post Herpetic Neuralgia (PHASE1, PHASE2)
• Double-blind Trial of Mannitol Cream to Block the Effect of Capsaicin Cream (NA)
• Trial of Mannitol Cream for Pain Relief After a Long Run (PHASE1)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.