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Mannitol (Aridol)
Mannitol is an osmotic agent that draws fluid into the airways to increase airway hydration and mucus clearance, used diagnostically to assess airway hyperresponsiveness.
Mannitol is an osmotic agent that draws fluid into the airways to increase airway hydration and mucus clearance, used diagnostically to assess airway hyperresponsiveness. Used for Diagnostic assessment of airway hyperresponsiveness in suspected asthma, Evaluation of exercise-induced bronchoconstriction.
At a glance
| Generic name | Mannitol (Aridol) |
|---|---|
| Sponsor | University of Saskatchewan |
| Drug class | Osmotic agent / Diagnostic bronchial challenge agent |
| Modality | Small molecule |
| Therapeutic area | Respiratory / Diagnostics |
| Phase | FDA-approved |
Mechanism of action
Mannitol powder is inhaled and acts as an osmotic agent, drawing water into the airway lumen and increasing airway surface liquid volume. This hydration of airways stimulates mast cell degranulation and airway smooth muscle contraction in individuals with airway hyperresponsiveness, making it useful as a bronchial challenge test to diagnose asthma and assess airway function.
Approved indications
- Bronchial challenge test for diagnosis of asthma and assessment of airway hyperresponsiveness
Common side effects
- Cough
- Throat irritation
- Wheezing
- Shortness of breath
- Chest tightness
Key clinical trials
- Effect of Infusion Warming on Mannitol Infusion Pain in Patients With Acute Ocular Hypertension (NA)
- Dose-dependent FODMAP Reintroduction in IBS (NA)
- Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants (PHASE3)
- Tesamorelin for Reduction of Liver Fat in Adults With Fatty Liver Disease (Mock Study) (PHASE2)
- Comparison of Changes in Intra-myocardial Amino Acids During Use of Calafiore and Modified Del Nido Cardioplegia
- Safety and Efficacy of AON-D21 in Severe Community-Acquired Pneumonia. (PHASE2)
- Mannitol Versus Nitroglycerin for Kidney Injury Prevention in Robotic-assisted Radical Prostatectomy or Cystectomy (NA)
- Does Caffeine Facilitate Human Reward Learning Behaviors? (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Mannitol (Aridol) CI brief — competitive landscape report
- Mannitol (Aridol) updates RSS · CI watch RSS
- University of Saskatchewan portfolio CI