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Maintenance on tacrolimus
Maintenance on tacrolimus is a Small molecule drug developed by Helio Tedesco Silva Junior. It is currently FDA-approved.
Tacrolimus is used as a maintenance immunosuppressive treatment for various conditions, including Type 1 Diabetes, Islet Transplantation, End Stage Renal Failure With Renal Transplant, Sickle Cell Disease, and Graft Versus Host Disease. It works by inhibiting the peptidyl-prolyl cis-trans isomerase FKBP1A through its action as a small molecule FK506-binding protein 1A inhibitor.
At a glance
| Generic name | Maintenance on tacrolimus |
|---|---|
| Sponsor | Helio Tedesco Silva Junior |
| Modality | Small molecule |
| Phase | FDA-approved |
Approved indications
Common side effects
Key clinical trials
- Fludarabine and Intermediate-dose TBI Followed by PTCy in Patients Undergoing Allo Transplant for Heme Malignancies (PHASE2)
- Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients (PHASE2)
- A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation (PHASE2)
- Trial of Cell Based Therapy for DMD (PHASE1)
- Advancing Transplantation Outcomes in Children (PHASE2)
- Valganciclovir Prophylaxis Versus Preemptive Therapy for Cytomegalovirus in Living Donor Kidney Transplant Recipients (PHASE4)
- Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia (PHASE2)
- Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Double Lung Transplant (BOSTON-2) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Maintenance on tacrolimus CI brief — competitive landscape report
- Maintenance on tacrolimus updates RSS · CI watch RSS
- Helio Tedesco Silva Junior portfolio CI
Frequently asked questions about Maintenance on tacrolimus
What is Maintenance on tacrolimus?
Who makes Maintenance on tacrolimus?
What development phase is Maintenance on tacrolimus in?
Related
- Manufacturer: Helio Tedesco Silva Junior — full pipeline
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing