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magnesium sulphate& levobupivacaine
Magnesium sulphate acts as a calcium channel blocker, while levobupivacaine is a local anesthetic that blocks sodium channels.
Magnesium sulphate acts as a calcium channel blocker, while levobupivacaine is a local anesthetic that blocks sodium channels. Used for General anesthesia, Spinal anesthesia.
At a glance
| Generic name | magnesium sulphate& levobupivacaine |
|---|---|
| Sponsor | South Egypt Cancer Institute |
| Drug class | Calcium channel blocker, Local anesthetic |
| Target | Calcium channels, Sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Magnesium sulphate's calcium channel blocking action helps to reduce muscle spasms and prevent seizures, while levobupivacaine's sodium channel blocking action numbs the area by preventing nerve impulses.
Approved indications
- General anesthesia, Spinal anesthesia
Common side effects
- Hypotension
- Respiratory depression
- Nausea and vomiting
Key clinical trials
- Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery (PHASE2)
- Efficacy of Magnesium Sulfate as an Adjuvant in Erector Spinae Plane Block as an Anesthetic Post Operative After Modified Radical Mastectomy (EARLY_PHASE1)
- Safety and Efficacy of Magnesium Sulphate as an Adjuvant to Levobupivacaine in Ultra-sound Guided Transversus Abdominis Plan Block in Pediatric Abdominal Cancer Surgery (PHASE3)
- Magnesium Sulfate in Combination With Dexmedetomidine As Adjuvants to Levobupivacaine (EARLY_PHASE1)
- Intraperitoneal Instillation of Levobupivacaine With Morphine Versus Levobupivacaine With Magnesium Sulfate for Postoperative Analgesia (PHASE4)
- Analgesic Efficacy of Magnesium Sulphate as an Adjuvant to Levobupivacaine in Erector Spinae Block for Acute Pain Management in Modified Radical Mastectomy (PHASE2, PHASE3)
- Analgesic Efficacy of Ultrasound Guided Erector Spinae Block for Modified Radical Mastectomy (PHASE2, PHASE3)
- Effect of Magnesium Sulphate on Analgesia Following Knee Arthroplasty (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- magnesium sulphate& levobupivacaine CI brief — competitive landscape report
- magnesium sulphate& levobupivacaine updates RSS · CI watch RSS
- South Egypt Cancer Institute portfolio CI