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Macrogol 3350 plus ascorbic acid
Macrogol 3350 plus ascorbic acid is an osmotic laxative bowel preparation that draws water into the intestinal lumen to promote evacuation, with ascorbic acid enhancing tolerability and reducing volume requirements.
Macrogol 3350 plus ascorbic acid is an osmotic laxative bowel preparation that draws water into the intestinal lumen to promote bowel evacuation. Used for Bowel cleansing prior to colonoscopy or other gastrointestinal procedures.
At a glance
| Generic name | Macrogol 3350 plus ascorbic acid |
|---|---|
| Sponsor | Fundación Canaria Rafael Clavijo para la Investigación Biomédica |
| Drug class | Osmotic laxative bowel preparation |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Macrogol 3350 (polyethylene glycol) is a non-absorbable osmotic agent that creates an osmotic gradient in the bowel, drawing fluid into the intestinal lumen and promoting bowel movement without systemic absorption. Ascorbic acid (vitamin C) is added to improve palatability and reduce the total volume of solution needed while maintaining efficacy for bowel cleansing prior to colonoscopy or other procedures.
Approved indications
- Bowel cleansing prior to colonoscopy or other gastrointestinal procedures
Common side effects
- Nausea
- Abdominal discomfort
- Bloating
- Vomiting
Key clinical trials
- Efficacy And Tolerability Of Asymmetric Split Regimen For Bowel Preparation (NA)
- Effect of Low-volume (1L) vs Intermediate-volume (2L) Bowel Preparation on Cost-effectiveness and Quality of Life (NA)
- Comparison of 1 Liter PEG With Ascorbate and Sodium Picosulfate / Magnesium Citrate for High Quality Colon Cleansing (PHASE4)
- Changes of Serum Electrolytes During Bowel Prep With PEG 3350 + Ascorbic Acid - a Prospective Study
- The Impact of Additional Oral Preparation on the Quality of Bowel Preparation for Colonoscopy (PHASE3)
- Comparison Between OSS and 2L PEG/Asc for Bowel Preparation of Elderly People (PHASE4)
- Colon Cleansing Quality of Polyethylene Glycol Compared With Polyethylene Glycol Plus Ascorbic Acid. (PHASE4)
- Bowel Preparation for Colonoscopy in the Elderly (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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