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Macrogol 3350 and electrolytes
Macrogol 3350 with electrolytes is an osmotic laxative that draws water into the bowel lumen to soften stool and promote bowel evacuation.
Macrogol 3350 with electrolytes is an osmotic laxative that draws water into the bowel lumen to soften stool and promote bowel evacuation. Used for Bowel cleansing prior to colonoscopy or other gastrointestinal procedures, Chronic constipation.
At a glance
| Generic name | Macrogol 3350 and electrolytes |
|---|---|
| Also known as | Gangiden |
| Sponsor | Odense University Hospital |
| Drug class | Osmotic laxative |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Macrogol 3350 (polyethylene glycol) is a non-absorbable polymer that creates an osmotic gradient in the intestinal lumen, retaining water and electrolytes to increase stool bulk and facilitate bowel movement. The added electrolytes (typically sodium chloride, potassium chloride, sodium bicarbonate, and sodium sulfate) help maintain electrolyte balance during bowel cleansing and prevent dehydration. This combination is commonly used for bowel preparation before colonoscopy or other gastrointestinal procedures.
Approved indications
- Bowel cleansing prior to colonoscopy or other gastrointestinal procedures
- Chronic constipation
Common side effects
- Nausea
- Abdominal bloating or distension
- Abdominal cramps
- Vomiting
- Headache
Key clinical trials
- What Laxative Should be Used After Hip Fracture Surgery? (PHASE4)
- Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen (PHASE4)
- A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy (PHASE4)
- Comparison of Efficacy & Tolerability Of PEG 4000 Versus PEG 3350+ Electrolytes for Pediatric Fecal Disimpaction (PHASE4)
- Lactulose vs. Polyethylene Glycol as Bowel Preparation for Colonoscopy in Adults (NA)
- Retrospective, Uncontrolled Cohort Study on the Therapy of Chronic Megalon
- Comparison of Clenpiq vs Golytely Bowel Preparation (PHASE4)
- Study Comparing the Bowel Cleansing Efficacy of PLENVU® Versus SELG-ESSE® Using a 2-Day Split Dosing Regimen. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Macrogol 3350 and electrolytes CI brief — competitive landscape report
- Macrogol 3350 and electrolytes updates RSS · CI watch RSS
- Odense University Hospital portfolio CI