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Endotoxin
Endotoxin is a Non-Standardized Food Allergenic Extract [EPC] Small molecule drug developed by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA). It is currently FDA-approved. Also known as: LPS, Lipopolysaccharide, Reference Endotoxin, CCRE.
Endotoxin, also known as lipopolysaccharide, is a component of the outermost membrane of Gram-negative bacteria such as E. coli and Salmonella. It is a small molecule with a common structural architecture, consisting of an outer core polysaccharide, an inner core oligosaccharide, and lipid A.
At a glance
| Generic name | Endotoxin |
|---|---|
| Also known as | LPS, Lipopolysaccharide, Reference Endotoxin, CCRE, CCRE Lot 94332B1 |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
| Drug class | Non-Standardized Food Allergenic Extract [EPC] |
| Modality | Small molecule |
| Therapeutic area | Other |
| Phase | FDA-approved |
Approved indications
Common side effects
Key clinical trials
- Effects of Bronchial Segmental Endotoxin Instillation in Humans (PHASE2)
- Inflammatory Challenge in Human Aggression. (PHASE2)
- Study of the Effect of Innate on the Inflammatory Response to Endotoxin
- Humidity Asthma Interventions for Low Socioeconomic Status Children (NA)
- Endotoxin Exposure to Examine the Role of Inflammation in Alcohol Use (PHASE2)
- Evaluation of the Outcome of Fecal Microbiota Transplantation (PHASE1, PHASE2)
- OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study
- Lipopolysaccharide Adsorption (Efferon LPS) in Patients With Ulcerative Colitis and Crohn Disease (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Endotoxin CI brief — competitive landscape report
- Endotoxin updates RSS · CI watch RSS
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) portfolio CI
Frequently asked questions about Endotoxin
What is Endotoxin?
Who makes Endotoxin?
Is Endotoxin also known as anything else?
What drug class is Endotoxin in?
What development phase is Endotoxin in?
Related
- Drug class: All Non-Standardized Food Allergenic Extract [EPC] drugs
- Manufacturer: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) — full pipeline
- Therapeutic area: All drugs in Other
- Also known as: LPS, Lipopolysaccharide, Reference Endotoxin, CCRE, CCRE Lot 94332B1