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Low oxygenation target
A clinical protocol that maintains lower blood oxygen saturation targets during patient care to reduce hyperoxia-related complications.
A clinical protocol that maintains lower blood oxygen saturation targets during patient care to reduce hyperoxia-related complications. Used for Acute respiratory distress syndrome (ARDS), Critically ill patients requiring mechanical ventilation, Post-cardiac arrest care.
At a glance
| Generic name | Low oxygenation target |
|---|---|
| Also known as | Inspired oxygen |
| Sponsor | Aalborg University Hospital |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Intensive Care Medicine |
| Phase | FDA-approved |
Mechanism of action
Low oxygenation target is a therapeutic strategy rather than a traditional drug, involving deliberate maintenance of lower oxygen saturation levels (typically 88-92%) in certain patient populations. This approach aims to minimize oxidative stress and inflammation associated with hyperoxia while avoiding hypoxia-related harm. The strategy has been studied primarily in critical care and post-resuscitation settings.
Approved indications
- Post-cardiac arrest care
- Critically ill patients requiring mechanical ventilation
Common side effects
- Hypoxemia if target set too low
- Potential increased mortality if oxygen deprivation occurs
Key clinical trials
- Transpulmonary Pressure-guided Mechanical Ventilation Strategy in Right Ventricular Protection in Patients With ARDS (NA)
- Acute Hemodynamic Responses to Blood Flow Restriction Aerobic Exercise in Interstitial Lung Disease (NA)
- Transpulmonary Assessment for Individualized Lung Optimization in Obese Patients (PHASE2)
- Intraoperative Multimodal Monitoring as a Means in Reducing the Duration of Mechanical Ventilation in High-Risk Patients Undergoing Major Abdominal Procedures - A Pilot Study (NA)
- Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19) (NA)
- Personalized Music Therapy for Preterm Infants (NA)
- Comparative Study Between Airway Pressure Release Ventilation and Pressure Regulated Volume Control (PRVC) in Protective Lung Strategy as a Recruitment Maneuver for Severe ARDS Mechanically Ventilated Patients Using Lung Ultrasound Score (NA)
- Understanding the Late Effects of Surviving a Pediatric Brain Tumor
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Low oxygenation target CI brief — competitive landscape report
- Low oxygenation target updates RSS · CI watch RSS
- Aalborg University Hospital portfolio CI