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Low dose oxcarbazepine
Low-dose oxcarbazepine reduces neuronal excitability by blocking voltage-gated sodium channels and modulating calcium channels in the brain.
Low-dose oxcarbazepine reduces neuronal excitability by blocking voltage-gated sodium channels and modulating calcium channels in the brain. Used for Epilepsy (adjunctive or monotherapy), Neuropathic pain, Bipolar disorder (off-label use).
At a glance
| Generic name | Low dose oxcarbazepine |
|---|---|
| Also known as | Low oxcarbazepine |
| Sponsor | Mario Negri Institute for Pharmacological Research |
| Drug class | Anticonvulsant / Antiepileptic drug |
| Target | Voltage-gated sodium channels; high-voltage-activated calcium channels |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | FDA-approved |
Mechanism of action
Oxcarbazepine is an anticonvulsant that primarily works by blocking voltage-dependent sodium channels, which stabilizes neuronal membranes and reduces repetitive neuronal firing. At low doses, it may also modulate high-voltage-activated calcium channels. The drug is a keto-analog of carbamazepine with a similar mechanism but potentially improved tolerability profile.
Approved indications
- Epilepsy (adjunctive or monotherapy)
- Neuropathic pain
- Bipolar disorder (off-label use)
Common side effects
- Hyponatremia
- Dizziness
- Somnolence
- Headache
- Ataxia
- Nausea
- Diplopia
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |