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low bile acid binding blenderized diet
A specialized blenderized diet formulation that minimizes bile acid binding to reduce enterohepatic circulation and modify lipid metabolism.
A specialized blenderized diet formulation that minimizes bile acid binding to reduce enterohepatic circulation and modify lipid metabolism. Used for Progressive familial intrahepatic cholestasis (PFIC) and related cholestatic liver diseases.
At a glance
| Generic name | low bile acid binding blenderized diet |
|---|---|
| Sponsor | Boston Children's Hospital |
| Drug class | Dietary intervention / Medical food |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology / Hepatology / Metabolic disorders |
| Phase | FDA-approved |
Mechanism of action
This dietary intervention is designed to reduce the binding of bile acids in the intestinal lumen, thereby decreasing their reabsorption and increasing fecal excretion. By limiting bile acid reabsorption, the diet may help normalize bile acid metabolism and reduce associated metabolic complications. This approach is particularly relevant for patients with certain cholestatic or metabolic disorders where bile acid accumulation contributes to disease pathology.
Approved indications
- Progressive familial intrahepatic cholestasis (PFIC) and related cholestatic liver diseases
Common side effects
- Gastrointestinal symptoms (diarrhea, steatorrhea)
- Nutritional deficiencies (fat-soluble vitamins)
- Palatability/compliance issues
Key clinical trials
- The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 3)
- The Use of High Bile-binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 2) (PHASE4)
- The Use of High Bile-binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 1) (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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