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loteprednol etabonate/tobramycin opthalmic suspension
loteprednol etabonate/tobramycin opthalmic suspension is a Corticosteroid/Aminoglycoside antibiotic combination Small molecule drug developed by Bausch & Lomb Incorporated. It is currently FDA-approved for Steroid-responsive inflammatory ocular conditions with bacterial infection or risk of bacterial infection, Post-operative ocular inflammation and infection prophylaxis. Also known as: Zylet.
Loteprednol etabonate reduces ocular inflammation via glucocorticoid receptor activation, while tobramycin provides broad-spectrum bacterial coverage by inhibiting bacterial protein synthesis.
Loteprednol etabonate reduces ocular inflammation via glucocorticoid receptor activation, while tobramycin provides broad-spectrum bacterial coverage by inhibiting bacterial protein synthesis. Used for Steroid-responsive inflammatory ocular conditions with bacterial infection or risk of bacterial infection, Post-operative ocular inflammation and infection prophylaxis.
At a glance
| Generic name | loteprednol etabonate/tobramycin opthalmic suspension |
|---|---|
| Also known as | Zylet |
| Sponsor | Bausch & Lomb Incorporated |
| Drug class | Corticosteroid/Aminoglycoside antibiotic combination |
| Target | Glucocorticoid receptor (loteprednol); bacterial ribosome 30S subunit (tobramycin) |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | FDA-approved |
Mechanism of action
Loteprednol etabonate is a corticosteroid that suppresses inflammatory mediators and immune responses in the eye. Tobramycin is an aminoglycoside antibiotic that binds to bacterial ribosomes and inhibits protein synthesis, providing coverage against gram-negative and gram-positive bacteria. The combination addresses both inflammatory and infectious components of ocular disease.
Approved indications
- Steroid-responsive inflammatory ocular conditions with bacterial infection or risk of bacterial infection
- Post-operative ocular inflammation and infection prophylaxis
Common side effects
- Ocular irritation or discomfort
- Conjunctival erythema
- Transient blurred vision
- Allergic reaction
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- loteprednol etabonate/tobramycin opthalmic suspension CI brief — competitive landscape report
- loteprednol etabonate/tobramycin opthalmic suspension updates RSS · CI watch RSS
- Bausch & Lomb Incorporated portfolio CI
Frequently asked questions about loteprednol etabonate/tobramycin opthalmic suspension
What is loteprednol etabonate/tobramycin opthalmic suspension?
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What is loteprednol etabonate/tobramycin opthalmic suspension used for?
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What drug class is loteprednol etabonate/tobramycin opthalmic suspension in?
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Related
- Drug class: All Corticosteroid/Aminoglycoside antibiotic combination drugs
- Target: All drugs targeting Glucocorticoid receptor (loteprednol); bacterial ribosome 30S subunit (tobramycin)
- Manufacturer: Bausch & Lomb Incorporated — full pipeline
- Therapeutic area: All drugs in Ophthalmology
- Indication: Drugs for Steroid-responsive inflammatory ocular conditions with bacterial infection or risk of bacterial infection
- Indication: Drugs for Post-operative ocular inflammation and infection prophylaxis
- Also known as: Zylet
- Compare: loteprednol etabonate/tobramycin opthalmic suspension vs similar drugs
- Pricing: loteprednol etabonate/tobramycin opthalmic suspension cost, discount & access