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loperamide ("Seldiar")
Loperamide is a mu-opioid receptor agonist that slows intestinal motility and reduces fluid secretion to decrease diarrhea.
Loperamide is a mu-opioid receptor agonist that slows intestinal motility and reduces fluid secretion to decrease diarrhea. Used for Acute diarrhea, Chronic diarrhea, Traveler's diarrhea.
At a glance
| Generic name | loperamide ("Seldiar") |
|---|---|
| Also known as | loperamide ("Seldiar"), Standard antidiarrhoeal drug |
| Sponsor | Marin Golčić |
| Drug class | Opioid antidiarrheal agent |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Loperamide binds to mu-opioid receptors in the enteric nervous system, which decreases peristalsis and increases absorption of water and electrolytes in the intestines. It has minimal systemic absorption and does not cross the blood-brain barrier at therapeutic doses, making it a peripherally selective opioid agonist with low abuse potential compared to systemic opioids.
Approved indications
- Acute diarrhea
- Chronic diarrhea
- Traveler's diarrhea
Common side effects
- Constipation
- Abdominal pain
- Nausea
- Dizziness
- Drowsiness
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |