Last reviewed · How we verify
Local steroid - triamcinolone acetonide
Triamcinolone acetonide is a synthetic corticosteroid that suppresses local inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
Triamcinolone acetonide is a synthetic corticosteroid that suppresses local inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Local inflammatory skin conditions (eczema, psoriasis, lichen planus), Intralesional treatment of keloids and hypertrophic scars, Intra-articular injection for inflammatory arthritis.
At a glance
| Generic name | Local steroid - triamcinolone acetonide |
|---|---|
| Sponsor | Instituto do Cancer do Estado de São Paulo |
| Drug class | Corticosteroid (glucocorticoid) |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Dermatology, Rheumatology, Immunology |
| Phase | FDA-approved |
Mechanism of action
As a potent glucocorticoid, triamcinolone acetonide reduces inflammation, immune cell infiltration, and vascular permeability at the site of administration. When applied locally (intralesional, topical, or intra-articular), it minimizes systemic exposure while delivering high local anti-inflammatory and immunosuppressive effects. It is commonly used to manage inflammatory and allergic conditions affecting skin, joints, and mucous membranes.
Approved indications
- Local inflammatory skin conditions (eczema, psoriasis, lichen planus)
- Intralesional treatment of keloids and hypertrophic scars
- Intra-articular injection for inflammatory arthritis
- Oral aphthous ulcers and oral lichen planus
Common side effects
- Local skin atrophy
- Skin depigmentation
- Telangiectasia
- Local infection at injection site
- Systemic corticosteroid effects (with prolonged use)
Key clinical trials
- Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone (PHASE4)
- Local Methotrexate Injections for the Treatment of Nail Psoriasis (PHASE4)
- Triamcinolone Acetonide Injection for Upper Eyelid Retraction in Thyroid Eye Disease (NA)
- A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD) (PHASE2)
- Comparison of Topical Calcipotriol and Intralesional Steroids in Alopecia Areata (PHASE4)
- The Effect of Local Corticosteroid Injection in Carpal Tunnel Syndrome Patients With Type 2 Diabetes
- Evaluation of the Efficacy of Suprascapular Nerve Block in Adhesive Capsulitis (NA)
- Frozen Shoulder and Hormone Replacement Therapy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: