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local anesthetic cream
Local anesthetic cream blocks sodium channels in nerve fibers to inhibit pain signal transmission at the site of application.
Local anesthetic cream blocks sodium channels in nerve fibers to inhibit pain signal transmission at the site of application. Used for Topical anesthesia for minor skin procedures, Relief of localized pain and itching.
At a glance
| Generic name | local anesthetic cream |
|---|---|
| Also known as | Placebo, Marcaine, local anesthetic administered paravertebrally, Chriocaina, Naropina |
| Sponsor | Yuzuncu Yil University |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Dermatology / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Local anesthetics work by penetrating the skin and mucous membranes to reach nerve endings and axons, where they reversibly block voltage-gated sodium channels. This prevents depolarization and propagation of action potentials, thereby interrupting pain sensation in the localized area without affecting systemic consciousness or motor function.
Approved indications
- Topical anesthesia for minor skin procedures
- Relief of localized pain and itching
Common side effects
- Skin irritation or erythema
- Contact dermatitis
- Allergic reaction
Key clinical trials
- Efficacy and Safety of Combined Nanofat Injection With Either Platelet Rich Fibrin or Microneedling Versus Nanofat Injection Alone in the Treatment of Facial Atrophic Post Acne Scars (NA)
- EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers (PHASE2)
- Efficacy of Sphenopalatine Block Compared to Blood Patch in the Management of Post-dural Puncture Headaches (PHASE3)
- Diminishing Accelerated Long-term Forgetting in Mild Cognitive Impairment (PHASE1, PHASE2)
- Evaluation of Paro, a Therapeutic Assistance Robot in Analgesic Management During the Placement of a Peripheral Intravenous Line in Infants and Children. (NA)
- Facial Muscle Exercises vs Fractional Microneedling Radiofrequency for Facial Rejuvenation (NA)
- Virtual Reality and Peripheral Intravenous Catheter Insertion to Children (R3VP) (NA)
- Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized Study (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- local anesthetic cream CI brief — competitive landscape report
- local anesthetic cream updates RSS · CI watch RSS
- Yuzuncu Yil University portfolio CI