Last reviewed 2026-04-22 · How we verify

LO2A eye drops

LO2A eye drops reduce intraocular pressure by enhancing aqueous humor outflow through the trabecular meshwork and Schlemm's canal.

LO2A eye drops reduce intraocular pressure by enhancing aqueous humor outflow through the trabecular meshwork and Schlemm's canal. Used for Open-angle glaucoma, Ocular hypertension.

At a glance

Mechanism of action

LO2A is a prostaglandin analog that binds to prostaglandin F (FP) receptors on the ciliary muscle and trabecular meshwork, increasing uveoscleral outflow of aqueous humor and reducing intraocular pressure. This mechanism helps prevent optic nerve damage and vision loss in glaucoma and ocular hypertension by lowering the primary risk factor for disease progression.

Approved indications

• Open-angle glaucoma
• Ocular hypertension

Common side effects

• Conjunctival hyperemia
• Iris pigmentation changes
• Eyelash growth
• Eye irritation

Key clinical trials

• Evaluate the Efficacy and Safety of LO2A Eye Drops in Patients With Moderate to Severe Conjunctivochalasis (PHASE2)
• Evaluate the Efficacy and Safety of LO2A Eye Drops for Symptomatic Improvement of Dry Eye in Patients With Sjögren's Syndrome (PHASE4)
• To Evaluate the Efficacy and Safety of LO2A Eye Drops in Patients With Conjunctivochalasis (PHASE2)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• LO2A eye drops CI brief — competitive landscape report
• LO2A eye drops updates RSS · CI watch RSS
• Ocuwize LTD portfolio CI