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LMX 4 Topical Cream
LMX 4 is a topical anesthetic cream containing 4% lidocaine that blocks sodium channels in nerve fibers to provide local pain relief.
LMX 4 is a topical anesthetic cream containing 4% lidocaine that blocks sodium channels in nerve fibers to provide local pain relief. Used for Topical anesthesia for minor procedures and dermatological applications, Relief of pain and itching associated with minor skin conditions.
At a glance
| Generic name | LMX 4 Topical Cream |
|---|---|
| Also known as | lidocaine, Lidocaine 4% |
| Sponsor | Rush University Medical Center |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Dermatology / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Lidocaine works by inhibiting sodium influx through sodium-selective ion channels in the nerve cell membrane, which stabilizes the neuronal membrane and prevents the initiation and conduction of nerve impulses. When applied topically, it penetrates the skin to provide localized anesthesia of the area of application. This mechanism allows for rapid onset of pain relief suitable for minor procedures and dermatological applications.
Approved indications
- Topical anesthesia for minor procedures and dermatological applications
- Relief of pain and itching associated with minor skin conditions
Common side effects
- Local skin irritation
- Erythema
- Allergic contact dermatitis
- Temporary blanching of skin
Key clinical trials
- Pain Control for Laser Epilation in Pilonidal Disease (PHASE4)
- Occipital Blocks for Acute Migraine (PHASE3)
- Fractional Ablative Laser Treatment for Skin Grafts (NA)
- Evaluation of Botulinum TOXin Type a in the Treatment of Buerger's Disease (PHASE3)
- Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With a Radiofrequency Microneedling for Facial Rejuvenation (NA)
- Topical Anaesthesia in Cutaneous Head and Neck Surgery (NA)
- Conservative Management of Cutaneous Abscess (PHASE4)
- Microneedle Versus Fractional CO₂ Laser for Skin Aging Treatment With Stem Cell Secretome in Indonesian Adult Women (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- LMX 4 Topical Cream CI brief — competitive landscape report
- LMX 4 Topical Cream updates RSS · CI watch RSS
- Rush University Medical Center portfolio CI