Last reviewed 2026-04-22 · How we verify

Listerine Experimental Mouthwash

Listerine Experimental Mouthwash kills oral bacteria and reduces plaque formation through its essential oil and antimicrobial active ingredients.

Listerine Experimental Mouthwash kills oral bacteria and reduces plaque formation through its essential oil and antimicrobial active ingredients. Used for Reduction of plaque and gingivitis, Halitosis (bad breath) control, General oral antimicrobial rinse.

At a glance

Mechanism of action

The mouthwash contains a combination of essential oils (eucalyptol, menthol, methyl salicylate, thymol) and other antimicrobial agents that disrupt bacterial cell membranes and inhibit microbial growth in the oral cavity. This reduces plaque accumulation, gingivitis, and halitosis by targeting pathogenic oral microorganisms.

Approved indications

• Reduction of plaque and gingivitis
• Halitosis (bad breath) control
• General oral antimicrobial activity

Common side effects

• Oral irritation or burning sensation
• Tooth staining
• Allergic reaction (rare)

Key clinical trials

• Clinical and Microbiological Comparison of 0.12% CHX and 0.05% CHX+0.05%CPC Mouthwashes in TPS Patients (NA)
• Determination of the Oral Irritation Potential of Two Alcohol-Free Rinses (NA)
• Anti-gingivitis Mouthrinse (PHASE3)
• A Two-Week Study of an Anticavity Low pH Mouthwash (PHASE4)
• A Clinical Study to Evaluate the Efficacy of a Range of Dental/Denture Products for Improved Oral Health in Partial Denture Wearers (PHASE4)
• A Study of Experimental Mouthwashes (PHASE4)
• Six Week Study of Experimental Mouth Rinses: Effect on Gingivitis and Plaque (PHASE1)
• A Twelve Week Study of Prototypes Mouth Rinses (PHASE4)

Primary sources

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