Last reviewed 2026-04-23 · How we verify

Liquid-stored platelets

Liquid-stored platelets are platelets preserved in liquid storage solution at refrigerated temperatures to maintain hemostatic function for transfusion.

Liquid-stored platelets are platelets preserved in liquid storage solution at refrigerated temperatures to maintain hemostatic function for transfusion. Used for Thrombocytopenia requiring platelet transfusion in critically ill patients, Perioperative platelet support.

At a glance

Mechanism of action

Traditional platelet transfusions require room-temperature storage, which limits shelf life and increases bacterial contamination risk. Liquid-stored platelets use specialized storage solutions and cold-chain preservation to extend shelf life and potentially reduce transfusion-related adverse events. This approach aims to improve platelet availability and safety in critical care settings.

Approved indications

• Thrombocytopenia requiring platelet transfusion in critically ill patients
• Perioperative platelet support

Common side effects

• Transfusion-related acute lung injury (TRALI)
• Febrile non-hemolytic transfusion reaction
• Alloimmunization
• Bacterial contamination / sepsis

Key clinical trials

• Platelet Rich Plasma Injections In Young And Old Human Subjects (PHASE2)
• DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS) (PHASE2, PHASE3)
• The Cryopreserved vs. Liquid Platelets Trial (PHASE3)
• Thrombosomes® in Bleeding Thrombocytopenic Patients Study (PHASE2)
• Phase 1 Safety Study of Dimethyl Sulfoxide Cryopreserved Platelets (PHASE1)
• Efficacy of Intra-articular Injection of Human Amniotic Suspension Allograft and Platelet-rich Plasma in the Treatment of Knee Osteoarthritis. (NA)
• Platelet Activating Factor Stability in Urine

Primary sources

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